Reference

Intoxication by orphenadrine hydrochloride; mechanism and therapy

Intoxication by orphenadrine hydrochloride; mechanism and therapy. Sangster, B.; Van Heijst, A. N. P.; Zimmerman, A. N. E.; De Vries, H. W. (Lab. Exp. Cardiol. Physiol. Circ., Univ. Hosp. Utrecht, Utrecht, Neth.). Acta Pharmacol. Toxicol., Suppl., 41(2), 129-36 (English) 1977. CODEN: APTSAI. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Orphenadrine-HCl (I) [341-69-5] (30 mg/kg, i.v.) decreased left ventricular contraction in dogs and, consequently, cardiac output and aortic pressure decreased. The cardiotoxicity of I was inhibited by i.v. injection of 0.6 mg droperidol (II) [548-73-2]/kg.

Stability-inducing assay for orphenadrine hydrochloride by reversed-phase high-performance liquid chromatography

Stability-inducing assay for orphenadrine hydrochloride by reversed-phase high-performance liquid chromatography. Selkirk, Sheila M.; Fell, Anthony F.; Smith, Geoffrey; Miller, John H. M. (Bangour Gen. Hosp., Broxburn EH52 6LR, UK). J. Chromatogr., 288(2), 431-44 (English) 1984. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Orphenadrine (I) [83-98-7] and its major degrdn. product o-methylbenzhydrol [5472-13-9] were detd. in tablets, injections, and syrup by chromatog. on a ODS-Hypersil column with pH 4.0 MeCN-50 mM KH2PO4 (1:1) contg. 40 mM Na dodecyl sulfate and diphenhydramine-HCl as internal std. The compds. were measured at 220 nm. The limits of detection were 10 ng for I and 1 ng for methylbenzhydrol. Recoveries were 99.5-100.4%. Oral liq. I-HCl [341-69-5] prepns. were more stable at pH 5 than at pH 2, 3, 4, or 7.