Detail of "3412-76-8"

Reference

Synthesis and antifungal activity of five classes of diamines

Ross, William F.; Walters, Dale R.; Robins, David J. (Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK). Pest Management Science, 60(2), 143-148 (English) 2004 John Wiley & Sons Ltd. CODEN: PMSCFC. ISSN: 1526-498X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 5, 10, 25 Examples of five classes of diamines were synthesized and tested for antifungal activity. Two classes, the bis(cyclohexylmethyl)diamines, RCH2NH(CH2)nNHCH2R (R = cyclohexyl, n = 3, 7, 8), and the bis(benzyl)diamines, RCH2NH(CH2)nNHCH2R (R = benzyl, n = 2, 7, 8, 9, 10), were most effective in reducing mycelial growth of the oat leaf stripe pathogen Pyrenophora avenae Ito & Kuribay when used at a concn. of 250 mM. The bis(benzyl)diamine, RCH2NH(CH2)nNHCH2R (R = benzyl, n = 10) (BBD5) and the hydroxypyridylethylamine, RCH(OH)CH2NEt2 (R = 2-pyridinyl) (HPE2), both reduced powdery mildew infection of barley seedlings by greater than 70% when applied as a post-inoculation spray at 250 mM. Several of the compds. examd., and esp. BBD5 and HPE2, reduced the formation of spermidine but greatly increased spermine levels. These changes in P avenae treated with BBD5 and HPE2 were also accompanied by greatly elevated activity of polyamine oxidase. 3412-76-8 which is the cas registry number is also used here. It is suggested that the antifungal activity of these compds. may be related to the accumulation of spermine and specifically to its toxicity. .