Detail of "34291-02-6"

Reference

Aminoglycoside 3'-phosphotransferase in Bacillus circulans producing butirosins

Aminoglycoside 3'-phosphotransferase in Bacillus circulans producing butirosins. Matsuhashi, Yuji; Sawa, Tsutomu; Kondo, Shinichi; Takeuchi, Tomio (Inst. Microb. Chem., Tokyo, Japan). J. Antibiot., 30(5), 435-7 (English) 1977. CODEN: JANTAJ. DOCUMENT TYPE: Journal CA Section: 16 (Fermentations) Aminoglycoside 3'-phosphotransferase [61393-90-6] in B. circulans transferred the phosphate from ATP to the 3'-hydroxyl group of butirosin A [34291-02-6], and this enzyme could be distinguished from enzymes in resistant strains by immunol. means.

Amikacin, an aminoglycoside with marked activity against antibiotic-resistant clinical isolates

Amikacin, an aminoglycoside with marked activity against antibiotic-resistant clinical isolates. Price, K. E.; DeFuria, M. D.; Pursiano, T. A. (Bristol Lab., Div., Bristol-Myers Co.Chemicals with cas numbers 37517-28-5 and 34493-98-6 also play role., Syracuse, N. Y., USA). J. Infect. Dis., 134(Suppl.), S249-S261 (English) 1976. CODEN: JIDIAQ. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) A total of 319 clin. isolates known to be resistant to .gtoreq.1 aminoglycoside antibiotic were tested for their susceptibility to 10 aminoglycosides. The susceptibility percentages of isolates found by an agar diln. method were: amikacin (I) [37517-28-5], 83.7%; tobramycin [32986-56-4], 41.4%; butirosin A [34291-02-6], 33.2%; dideoxykanamycin B [34493-98-6], 32.6%; gentamicin C [11097-82-8], 27.3%; lividomycin A [36441-41-5], 17.6%; neomycin B [119-04-0], 10.7%; paromomycin [7542-37-2], 10.3%; kanamycin A [59-01-8], 10.0%; and ribostamycin [25546-65-0], 7.2%. The effectiveness of the antibiotics was related to their degree of resistance to bacterial enzymes; e.g., of the 9 enzymes known to inactivate antibiotics contg. 2-deoxystreptamine, I was affected by 1 enzyme, tobramycin by 5, and gentamicin and kanamycin by 6. Examn. of cell-free exts. from the 52 strains resistant to I revealed that only 4 contained the I-inactivating enzyme aminoglycoside-6'-acetyltransferase [56467-65-3]. Most I-resistant strains, which were almost invariably resistant to all aminoglycosides, lacked the ability to accumulate effectively either I or presumably the other antibiotics intracellularly. .