Reference

Effects of benserazide on tryptophan metabolism in the mouse

Effects of benserazide on tryptophan metabolism in the mouse. Bender, David A.; Smith, William R. D.; Humm, R. Paul (Med. Sch., Middlesex Hosp., London, Engl.). Biochem. Pharmacol., 26(17), 1619-23 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 Benserazide (I) [322-35-0] (50 .mu.g/g tissue) totally inhibited liver kynureninase (EC 3.7.1.3) (II) [9024-78-6] and kynurenine aminotransferase (EC 2.6.1.7) [9030-38-0] activities and even at concns. of 2.5 .mu.g/g (similar to doses used in treatment of Parkinson's disease) significant inhibition was obsd. I (200 .mu.g/g) had no effect on tryptophan oxygenase (EC 1.13.11.11) [9014-51-1]. Xanthurenic acid [59-00-7] excretion following a tryptophan (III) [73-22-3] load was not affected by I unless it was administered at the same time as the III load. I (50 mg/kg) and a III load increased liver kynurenine [343-65-7]. Evolution of 14CO2 following III-2-14C injection showed that the prodn. of 14CO2 from III-1-14C could be due to metab. of alanine [56-41-7] released by the action of II. One effect of this reduced oxidative metab. of III would be reduced formation of nicotinamide [98-92-0] and the possibility that patients treated with I may show niacin [59-67-6] deficiency.

Kynurenine antagonism against 5-HTP-potentiated action of imipramine and amitriptyline in frogs

Kynurenine antagonism against 5-HTP-potentiated action of imipramine and amitriptyline in frogs. Lapin, I.; Jagiello-Wojtowicz, Ewa (Psychopharmacol. Lab., V. M. Bekhterev Inst. Psychoneurol., Leningrad, USSR). Acta Physiol. Pol., 27(6), 591-4 (English) 1976. CODEN: APYPAY. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Imipramine [50-49-7] and amitriptyline [50-48-6] (10 mg/kg into the dorsal lymphatic sac) administered together with 5-hydroxytryptophan (5-HTP) [59-67-6] (100 mg/kg) caused disappearance of the righting reflex in frogs. Kynurenine (I) [343-65-7], 3-hydroxyanthranilic acid [548-93-6], anthranilic acid [118-92-3], picolinic acid [98-98-6], nicotinic acid [59-67-6], and quinolinic acid [89-00-9] (25 mg/kg) abolished this effect.