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CAS No.: | 3430-19-1 |
---|---|
Name: | 5-Methylpyridin-3-amine |
Article Data: | 11 |
Molecular Structure: | |
Formula: | C6H8N2 |
Molecular Weight: | 108.143 |
Synonyms: | 3-Picoline,5-amino- (7CI,8CI);(5-Methylpyridin-3-yl)amine;3-Amino-5-methylpyridine;5-Methyl-3-pyridinamine; |
EINECS: | 624-420-4 |
Density: | 1.068 g/cm3 |
Melting Point: | 59-63 °C |
Boiling Point: | 261.1 °C at 760 mmHg |
Flash Point: | 135.6 °C |
Appearance: | COLORLESS TO YELLOW SOLID |
Hazard Symbols: | T, Xi, Xn |
Risk Codes: | 22-37/38-41-20/21/22 |
Safety: | 26-36/37/39 |
PSA: | 38.91000 |
LogP: | 1.55340 |
Conditions | Yield |
---|---|
With potassium hydroxide; bromine 1.) RT, 1 h, 2.) 70 deg C, 15 min; | 67% |
With sodium hydroxide; bromine In tetrahydrofuran at 5 - 70℃; Hoffmann rearrangement; |
2-amino-3-methyl-5-nitropyridine
5-methylpyridin-3-amine
Conditions | Yield |
---|---|
With hydrazine In water at 110 - 120℃; for 5h; | 45% |
Multi-step reaction with 3 steps 1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: phosphoryl chloride 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme | |
Multi-step reaction with 2 steps 1: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme |
Conditions | Yield |
---|---|
With hydrazine In water at 110 - 120℃; for 5h; | 41% |
2-chloro-3-methyl-5-nitropyridine
5-methylpyridin-3-amine
Conditions | Yield |
---|---|
With palladium on activated charcoal; sodium acetate; acetic acid Hydrogenation; |
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 27 percent / potassium permanganate / H2O / 1.) from RT to 43 deg C, 5 h, 2.) 45 deg C, overnight 2: thionyl chloride / Heating 3: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 4: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / Heating 2: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 3: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme |
5-methyl-nicotinic acid chloride
5-methylpyridin-3-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonia gas / 1,2-dichloro-ethane / 0.5 h / -30 °C 2: 67 percent / bromine, aq. potassium hydroxide / 1.) RT, 1 h, 2.) 70 deg C, 15 min View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: phosphoryl chloride 4: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme | |
Multi-step reaction with 3 steps 1: H2SO4; HNO3 2: calcium chloride; aqueous sodium nitrite solution; aqueous hydrochloric acid / Erhitzen des Reaktionsprodukts mit Wasser 3: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme |
2-hydroxy-3-methyl-5-nitropyridine
5-methylpyridin-3-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosphoryl chloride 2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation View Scheme |
2-bromo-3-methyl-5-nitropyridine
5-methylpyridin-3-amine
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In methanol |
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Molecule structure of 3-Amino-5-Methylpyridine (CAS NO.3430-19-1) :
IUPAC Name: (2S)-2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid
Molecular Weight: 215.6336 g/mol
Molecular Formula: C9H10ClNO3
Density: 1.068 g/cm3
Melting Point: 59-63 °C
Boiling Point: 261.1 °C at 760 mmHg
Flash Point: 135.6 °C
Molar Volume: 101.2 cm3
Polarizability: 13.24*10-24 cm3
Surface Tension: 46.9 dyne/cm
Enthalpy of Vaporization: 49.88 kJ/mol
Vapour Pressure: 0.0118 mmHg at 25 °C
XLogP3: -1.8
H-Bond Donor: 3
H-Bond Acceptor: 4
Rotatable Bond Count: 3
Tautomer Count: 3
Exact Mass: 215.034921
MonoIsotopic Mass: 215.034921
Topological Polar Surface Area: 83.6
Heavy Atom Count: 14
Complexity: 212
Defined Atom StereoCenter Count: 1
Canonical SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)Cl)O
Isomeric SMILES: C1=CC(=C(C=C1C[C@@H](C(=O)O)N)Cl)O
InChI: InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChIKey: ACWBBAGYTKWBCD-ZETCQYMHSA-N
Product Categories of 3-Amino-5-Methylpyridine (CAS NO.3430-19-1) : VARIOUSAMINE; Heterocyclic Compounds; Amino; Intermediate; Pyridine; Boronic Acid; Heterocyclic Building Blocks; Pyridines; Building Blocks
Hazard Codes: T, Xi, Xn
Risk Statements: 22-37/38-41-20/21/22
R22: Harmful if swallowed
R37/38: Irritating to respiratory system and skin
R41:Risk of serious damage to the eyes
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 26-36/37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S36: Wear suitable protective clothing
Hazard Note: Toxic
3-Amino-5-Methylpyridine (CAS NO.3430-19-1) is also called 3-Amino-5-picoline ; 5-Methyl-pyridin-3-ylamine ; 3-Amino-5-methylpyridine97% ; 3-Pyridinamine,5-methyl-(9CI) ; 5-Methyl-3-pyridylamine hydrochloride salt ; 5-Methyl-3-pyridinamine ; 5-Amino-3-methylpyridine .