Reference

Synthesis and biologic distribution of radioiodinated b-adrenergic antagonists

Synthesis and biologic distribution of radioiodinated b-adrenergic antagonists. Hanson, Robert N.; Holman, B. Leonard; Davis, Michael A. (Dep. Radiol., Harvard Med. Sch. 3506-09-0 is also in the experiment., Boston, Mass., USA). J. Med. Chem., 21(8), 830-3 (English) 1978. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8, 26 Radioiodinated analogs of (±)-propranolol-HCl (I-HCl) [3506-09-0], practolol-HCl [6996-43-6], and acebutolol [34381-68-5] were prepd. and their tissue distribution examd. in rats. Radioisotopic exchange between carrier-free Na125I and the molten iodinated adrenergic antagonist yielded the corresponding labeled compd. The tissue distribution in rats, detd.In this study，3506-09-0 is also used. 15 and 60 min after i.v. administration, indicated that the radioiodinated analogs of the cardioselective drugs practolol and acebutolol localized to a greater degree in the liver and heart than did I which concd. to a greater extent in the lungs. Therefore, 123I- or 131I-labeled cardioselective b-adrenergic antagonists may prove useful as radiodiagonistic agents for the external imaging of the myocardium. ..

Absorption and excretion of acebutolol hydrochloride preparations

Absorption and excretion of acebutolol hydrochloride preparations. Awata, Norio; Fujiwara, Shigeru; Sugimoto, Isao; Sato, Hisashi; Hori, Hiroaki; Hoshi, Hiroshi (Pharm. Res. Cent., Kanebo Ltd., Osaka, Japan). Iyakuhin Kenkyu, 9(1), 141-7 (Japanese) 1978. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) After oral administration of acebutolol-HCl (I-HCl) [34381-68-5] (100 mg) to dogs, the plasma level reached a max. at 1 h and decreased with a half-life of 2.3 h. Analysis of urinary metabolites showed that most of I was unchanged. In humans receiving I, more than half of I administered was acetylated.