Reference

Evaluation of chloropentafluorobenzene in a battery of in vitro short term assays

Evaluation of chloropentafluorobenzene in a battery of in vitro short term assays. Tu, Alice S.; Broome, Mildred G.; Sivak, Andrew (Little (Arthur D.), Inc., Cambridge, MA, USA). Report, AAMRL-TR-86-003; Order No. AD-A165849/1/GAR, 39 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1986, 86(14), Abstr. No. 631,095 (English) 1986. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) A fully substituted halogenated benzene, chloropentafluorobenzene [344-07-0], was evaluated in a battery of in vitro short-term bioassays to assess its potential biol. activity. The assays conducted were Ames Salmonella/mammalian microsomal mutagenicity assay, the CHO gene mutation assay, the CHO/sister chromatid exchange and chromosome aberrations assay, a DNA repair assay utilizing primary rat hepatocytes and the BALB/c-3T3 cell transformation assay. The test compd., although a liq., pptd. out of soln. in solvents compatible with the bioassays. Therefore, the actual sol. concns. in the test medium were not known. Under these conditions, chloropentafluorobenzene produced a pos. response in the CHO/chromosome aberrations assay and in the primary rat hepatocyte/DNA repair assay but was not active in the remaining 4 in vitro assays.

Rapid, physiologically based method for evaluating candidate chemical warfare agent uptake simulants

Rapid, physiologically based method for evaluating candidate chemical warfare agent uptake simulants. Jepson, G. W.; Clewell, H. J.; Andersen, M. E. (Harry G. Armstrong Aerosp. Med. Res. Lab., Wright-Patterson AFB, OH, USA). Report, AAMRL-TR-85-045; Order No. AD-A159152/8/GAR, 16 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1986, 86(1), Abstr. No. 601,322 (English) 1985. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) Potential chem. warfare agent uptake simulants were selected and evaluated using a physiol. based method. Measurements of the partitioning of a chem. in body tissues and its phys. properties, together with animal exposures in a closed chamber system interpreted by kinetic modeling, provided a rapid means of assessing the conformance of a particular chem. to criteria established for a useful simulant. A potential chem. warfare agent uptake simulant should as a min. (1) have phys. properties that allow for generation of realistic exposure conditions for the agent being simulated, (2) have good detectability, (3) be very poorly metabolized (biol. inert), and (4) be safe to humans in the concns. to be encountered. Perfluorochems. representing both aliph. and arom. compds. were used as initial candidates since they afford excellent detectability and relative biol. inertness. Analogs of the initial compds. were subsequently tried until satisfaction of the established criteria was obtained. The required changes in chem. structure were driven by predictions from a physiol. based computer model. The main thrust of this report is to outline the application of physiol. modeling to the important task of chem. warfare agent uptake simulant selection (design). Chloropentafluorobenzene [344-07-0] was identified as a potential uptake simulant for nonpersistent chem. warfare agents.