Detail of "34562-97-5"

CAS Number:
34562-97-5
Name:
Butanoic acid,4-[(3-pyridinylcarbonyl)amino]-
Superlist Name:
Pikamilone
Molecular Structure:
Formula:
C₁₀H₁₂N₂O₃
Molecular Weight:
208.22
Synonyms:
Butyricacid, 4-nicotinamido- (7CI);4-[(3-Pyridinylcarbonyl)amino]butanoic acid;N-Nicotinoyl-g-aminobutyricacid;Nicotinoyl-GABA;Nicotinoyl-g-aminobutyric acid;
Density:
1.245 g/cm³
Boiling Point:
522.4 °C at 760 mmHg
Flash Point:
269.8 °C
Appearance:
white crystalline powder
Hazard Symbols:
Xi

Supplier Location
Supplier Location
- China (Mainland)(20)
Business Type
Business Type
- Lab/Research institutions(3)
- Manufacturers(1)
- Trading Company(14)
Certificates
Certificates
- ISO(3)
- Production License(1)
Exhibitions
Exhibitions

Display：

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Evaluation of isonicotinoyl-g-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA: Evaluation of isonicotinoyl-g-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA. Matsuyama, Kenji; Yamashita, Chikamasa; Noda, Atsuko; Goto, Shigeru; Noda, Hiroshi; Ichimaru, Yasuyuki; Gomita, Yutaka (Fac. Pharm. Sci., Kyushu Univ., Fukuoka 812, Japan). Chem. Pharm. Bull., 32(10), 4089-95 (English) 1984. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Isonicotinoyl-GABA (IG) [34562-97-5] and nicotinoyl-GABA (NG) [34562-97-5], candidate prodrugs of GABA [56-12-2], were assessed by measuring various pharmacol. responses such as anticonvulsant effect, prolongation of pentobarbital [76-74-4] sleeping time, and depressive effect on rearing or ambulation in general behavior, in relation to the GABA level in the mouse brain. The GABA level after the i.p. administration of IG at a dose of 1000 mg/kg increased significantly from 2.30 mmol/g wet wt. in the control to 2.93 mmol/g wet wt., whereas NG caused only a slight increase in GABA level. IG showed a stronger anticonvulsant effect, greater prolongation of pentobarbital sleeping time, and greater depressive effect on rearing in general behavior than NG did. The pharmacol. effect of IG or NG corresponded well to the GABA level in the brain.

Pharmacological correction of traumatic brain edema: Pharmacological correction of traumatic brain edema. Novikov, V. E.; Yasnetsov, V. S. (Smolensk.Some commonly used reagents like 56-12-2 and 127-17-3 are used in this experiment. Med. Inst., Smolensk, USSR). Farmakol. Toksikol. (Moscow), 47(1), 34-7 (Russian) 1984. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Diazepam [439-14-5], phenazepam [51753-57-2], and phenibut [1078-21-3] markedly inhibited the development of exptl. traumatic edema in the brains of rats and counteracted trauma-induced increases in the lactate [50-21-5]/pyruvate [127-17-3] index. Pantogam [17097-76-6], nicotinoyl-GABA [34562-97-5], and piracetam [7491-74-9], however, were ineffective. The antiedematous activity of the 1st 3 drugs appears to involve the activation of brain GABAergic systems, as well as the participation of adreno- and cholinoreactive structures involved in brain metab. .