Detail of "3463-21-6"

CAS Number:
3463-21-6
Name:
2,8,9-Trioxa-5-aza-1-silabicyclo[3.3.3]undecane,1-ethoxy-
Molecular Structure:
Formula:
C8H17 N O4 Si
Molecular Weight:
219.35
Synonyms:
Ethanol,2,2',2''-nitrilotri-, cyclic ethyl silicate (6CI); Silicic acid, cyclicnitrilotriethylene ethyl ester (7CI); Ethanol, 2,2',2''-nitrilotri-, cyclicester with silicic acid (H4SiO4) ethyl ester (8CI); Silicic acid (H4SiO4),ethyl ester, cyclic ester with 2,2',2''-nitrilotriethanol (8CI);1-Ethoxysilatrane; Ethoxysilatrane; Migugen; Silicic acid (H4SiO4), cyclicnitrilotriethylene ethyl ester
Density:
1.14g/cm³
Melting Point:
100°C
Boiling Point:
180°C 0,6mm
Flash Point:
110.4°C
Safety:
Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NO_x. Details

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Effect of some organosilicon compounds (silatranes) on the biosynthesis of collagen in cartilagenous tissue of chick embryos: Effect of some organosilicon compounds (silatranes) on the biosynthesis of collagen in cartilagenous tissue of chick embryos. Simkhovich, B. Z.; Lukevics, E.; Zelcan, G.; Zamaraeva, T. V.; Mazurov, V. I. (Inst. Org. Synth., Riga, USSR). Biokhimiya (Moscow), 42(6), 1128-33 (Russian) 1977. CODEN: BIOHAO. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Methylsilatrane [2288-13-3], ethoxysilatrane [3463-21-6], and chloromethylsilatrane [42003-39-4] stimulated total protein synthesis and collagen synthesis in cartilage tissue from chick embryos. Methylsilatrane was the most effective with respect to total protein synthesis. Collagen synthesis, as measured by formation of peptide-bound hydroxyproline-14C from proline-14C in the incubation medium, was most strongly stimulated by all 3 silatrane derivs. at 3 .times. 10-3M concn. with a 180-min incubation period. The silatranes did not affect collagen proline hydroxylase activity, indicating their effect on collage formation is an indirect one involving the protein-synthesizing app. of the cell.

Silatranes - stimulators of productivity in mulberry silkworms: Silatranes - stimulators of productivity in mulberry silkworms. Vititnev, I. V.; Shkaruba, N. G.; Drozda, V. F. (Ukr. S-kh. Akad., Kiev, USSR). Integr. Zashch. Rast. Vred. Bolezn. S-kh. Kul't., 58-61. Edited by: Kirik, I. N. Ukr. S-kh. Akad.: Kiev, USSR. (Russian) 1983. CODEN: 50UJAO. DOCUMENT TYPE: Conference CA Section: 18 (Animal Nutrition) Dietary administration of 0.5-12.5 mg/caterpillar, within instars 3-5, of silatranes (Si derivs. of amino alcs.) synthesized by the Irkutsk Institute of Org. Chem., enhanced silkworm growth. Isomigugen (1-ethoxy-3,7,10-trimethylsilatrane) [18051-99-5] increased the total wt. of female and male cocoons by 18.3 and 4.2%, resp., the wt. of the silk coating by 127.1 and 113.7%, and the wt. of pupae by 16 and 1.9%, resp. Migugen [3463-21-6] also increased the silk yield in a sex-dependent manner, without increasing the pupal wt. Mival thiuronium salt was effective only in the lowest dose, because its S odor discouraged feed intake. The results confirm the essential role of Si in the animal metab. and the specific action of silatranes on the protein metab.