Reference

Pyridopyrimidinetriones, their use, and drugs containing them

Pyridopyrimidinetriones, their use, and drugs containing them. Klemm, Kurt; Pruesse, Wolfgang; Baron, Lothar; Kilian, Ulrich; Sanders, Karl (Byk-Gulden Lomberg Chemische Fabrik G.m.b.H., Fed. Rep. Ger.). Ger. Offen. DE 3326118 A1 9 Feb 1984, 50 pp. (German). (Germany).Chemical with cas number 34654-81-4 also plays role. CODEN: GWXXBX. CLASS: IC: C07D471-04; A61K031-505. APPLICATION: DE 83-3326118 20 Jul 1983. PRIORITY: CH 82-4651 2 Aug 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Title compds. (I) (R = H, C1-5 alkyl; R1 = C1-5 alkyl; R2 = H, C1-3 alkyl; R3 = H, halo, C1-4 alkyl or alkoxy, CF3; R4 = H, halo, C1-4 alkyl or alkoxy) and their N-oxides and salts were prepd. and shown to have antihypertensive activity. Thus, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethylurac il was added to CH2:CHCO2Et, and the product sapond., then cyclized by heating 1 h at 140°/12-15 mbar to give the pyridopyrimidinetrione II. .