Reference

Studies on the metabolism of flavoxate hydrochloride

Studies on the metabolism of flavoxate hydrochloride. Inoue, Sho; Sugiyama, Makoto; Tatewaki, Nobukiyo; Ando, Tomini; Kono, Tatsuhiko; Fujioka, Miyuki (Res. Lab., Nippon Shinyaku Co. Ltd., Kyoto, Japan). Iyakuhin Kenkyu, 6(3), 267-76 (Japanese) 1975. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The main metabolite of flavoxate-HCl (I-HCl) [3717-88-2] in rat urine within 24 h after administration was 8-carboxy-3-methylflavone (II) [3468-01-7] and the minor metabolites were presumably 8-carboxy-3-hydroxymethylflavone (III) [66063-55-6] and conjugates of II and III. Intact I was not detected in the urine. In the dog, a small amt. of unchanged I was detected in urine. The major metabolite was II. The metabolites in rat bile were largely II and III conjugates. Differences in I metab. among several lab. animals were demonstrated.

Urinary kinetics and tolerability of oral flavoxate in humans

Urinary kinetics and tolerability of oral flavoxate in humans. Benvenuti, C.; Cova, A.; Simonazzi, I. (Div. Med. Rich., Recordati, Milan, Italy). Farmaco, Ed. Prat., 32(2), 99-107 (Italian) 1977. CODEN: FRPPAO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Healthy persons given 600 mg flavoxate-HCl (I-HCl) [3717-88-2]/day, orally, for 7 days excreted 48% of the 1st day's dose in the 1st 24-h urine; the percentage increased to .apprx.60% in the 3rd day's urine and then remained essentially const. till day 7. This excretion pattern excludes an accumulation of I in the body.There are some commonly used reagents with their cas registry numbers 3717-88-2 and 3468-01-7 in this article. About 40% of the I-derived material in the urine was in the free form, and the quant. patterns of these substances did not vary significantly from day to day. The free material was composed mainly of 3-methylflavone-8-carboxylic acid [3468-01-7] (<40% of the free metabolites), a hydroxylated product (>40%), and a 2nd unidentified metabolite (<20%). Free I was excreted only in small amts. I was perfectly tolerated at this dose by the subjects, as shown by blood and urine analyses. .