Reference

Expedited SAR study of high-affinity ligands to the a2d subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology

Chen, Chixu; Stearns, Brian; Hu, Tao; Anker, Naomi; Santini, Angelina; Arruda, Jeannie M.; Campbell, Brian T.Several substances are used for example 2393-23-9 and 34698-41-4 which are their cas registry numbers.; Datta, Purabi; Aiyar, Jayashree; Munoz, Benitio (Department of Chemistry, Merck Research Laboratories, San Diego, CA 92121, USA). Bioorganic & Medicinal Chemistry Letters, 16(3), 746-749 (English) 2006 Elsevier B.V. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The SAR of the lead compd. 3, a novel ligand for the a2d subunit of voltage-gated calcium channels, was rapidly explored. Utilizing a parallel soln.-phase Sn2Ar coupling approach, a focused library was obtained. The library was evaluated in vitro and afforded a series of analogs with improved potencies. The SAR trends of the library are also described. .