Detail of "3470-98-2"

Reference

Transdermal tapes containing accelerators of drug transport in the skin

Transdermal tapes containing accelerators of drug transport in the skin. (Nitto Electric Industrial Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58208216 A2 3 Dec 1983 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K009-70; A61K047-00; A61L015-03. 59227-89-3 is also in the experiment. APPLICATION: JP 82-91831 28 May 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Transdermal tapes contg. I (R = H or C1-4 alkyl; n = 3-7; n = 0 or 1-11) such as 1-dodecylazacycloheptan-2-one [59227-89-3] and 1-butylazacyclopentan-2-one [3470-98-2] which accelerate the drug absorption through the skin. Thus, acrylic acid-2-ethylhexyl acrylate copolymer [25134-51-4] 100, 1-dodecylazacycloheptan-2-one 10, and propatyl nitrate 7 parts were mixed, spread 50 mm thick over a polyethylene film, and dried to obtain a transdermal tape. .

Raman spectroscopic study of hydrogen bonding of N-alkyl-2-pyrrolidinones in heavy water

Raman spectroscopic study of hydrogen bonding of N-alkyl-2-pyrrolidinones in heavy water. Tanaka, Naoki; Ito, Kensaku; Kitano, Hiromi; Ise, Norio (Dep.Some chemicals with cas registry numbers like 3470-98-2 and 1333-74-0 are also used. Polym. Chem., Kyoto Univ., Kyoto 606, Japan). Spectrochim. Acta, Part A, 48A(2), 237-43 (English) 1992. CODEN: SAMCAS. ISSN: 0584-8539. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) The Raman spectra of D2O solns. of N-methyl-, N-ethyl-, and N-n-butyl-2-pyrrolidinone under diverse conditions were measured. Using a computer fitting of the band shape of the carbonyl stretching mode at various temps., an enthalpy difference for the inversion motion at the nitrogen atom due to hydrogen bonding with deuterium was estd. for these compds. The enthalpy difference of hydrogen bond formation to the nitrogen atom of N-methyl-2-pyrrolidinone at 30 wt % in D2O (mole fraction 0.080) was greater than that of N-methyl-2-pyrrolidinone in an aq. soln. at a mole fraction of 0.406. Furthermore, the enthalpy difference of N-alkyl-2-pyrrolidinones increased with the alkyl chain length. This is interpreted as a result of the change of the hydrophobic hydration of D2O mols. around the solute mols. .