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3473-63-0

Basic Information
CAS No.: 3473-63-0
Name: Formamidine acetate
Article Data: 3
Molecular Structure:
Molecular Structure of 3473-63-0 (Formamidine acetate)
Formula: C2H4O2.CH4N2
Molecular Weight: 104.109
Synonyms: Methanimidamide monoacetate;
EINECS: 222-442-5
Density: 1.124 g/cm3
Melting Point: 158-161 °C (dec.)(lit.)
Boiling Point: 117.1 °C at 760 mmHg
Flash Point: 40 °C
Solubility: 832 g/L (21 °C) in water
Appearance: white to light yellow crystalline powder
Hazard Symbols: IrritantXi
Risk Codes: 43-36/37/38
Safety: 36/37-37/39-26-36/37/39-27
PSA: 87.17000
LogP: 0.44310
Synthetic route
122-51-0

orthoformic acid triethyl ester

3473-63-0

formamidine acetic acid

Conditions
ConditionsYield
With ammonia; acetic acid80%
420-04-2

CYANAMID

64-19-7

acetic acid

3473-63-0

formamidine acetic acid

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In water for 3.5h;63%
64-19-7

acetic acid

122-51-0

orthoformic acid triethyl ester

3473-63-0

formamidine acetic acid

Conditions
ConditionsYield
With ammonia Reflux;
951655-39-3

C14H13BrN2O2

3473-63-0

formamidine acetic acid

951655-40-6

C15H11BrN2O2

Conditions
ConditionsYield
In 2-methoxy-ethanol at 100℃; for 4h;100%
1402559-18-5

benzyl N-[4-(3-amino-2-cyano-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)phenyl]carbamate

3473-63-0

formamidine acetic acid

1402558-20-6

benzyl N-[4-(4-amino-7,8-dihydro-6H-cyclopenta[2,3]pyrrolo[2,4-d]pyrimidin-5-yl)phenyl]carbamate

Conditions
ConditionsYield
In ethanol at 80℃; for 3h;100%
In ethanol at 80℃; for 1.5h;
3473-63-0

formamidine acetic acid

52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

69981-00-6

7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 2.5h; Inert atmosphere; Reflux; Large scale;100%
150812-32-1

2-amino-4-bromo-5-chlorobenzoic acid

3473-63-0

formamidine acetic acid

17518-98-8

4-hydroxy-6-chloro-7-bromo-quinazoline

Conditions
ConditionsYield
In ethanol for 16h; Reflux;100%
In ethanol for 16h; Reflux;

benzyl N-[4-(3-amino-2-cyano-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-2-methoxyphenyl]carbamate

3473-63-0

formamidine acetic acid

benzyl N-[4-(4-amino-7,8-dihydro-6H-cyclopenta[2,3]pyrrolo[2,4-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate

Conditions
ConditionsYield
In ethanol at 80℃; for 3h; Inert atmosphere;100%

benzyl N-[4-(3-amino-2-cyano-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-2-(trifluoromethyl)phenyl]carbamate

3473-63-0

formamidine acetic acid

benzyl N-[4-(4-amino-7,8-dihydro-6H-cyclopenta[2,3]pyrrolo[2,4-d]pyrimidin-5-yl)-2-(trifluoromethyl)phenyl]carbamate

Conditions
ConditionsYield
In ethanol for 4h; Reflux;100%
1402559-15-2

benzyl N-[4-(3-amino-2-cyano-5,6-dihydro-4H-cyclopenta[b]pyrrol-1-yl)-2-fluorophenyl]carbamate

3473-63-0

formamidine acetic acid

1402558-98-8

benzyl N-[4-(4-amino-7,8-dihydro-6H-cyclopenta[2,3]pyrrolo[2,4-d]pyrimidin-5-yl)-2-fluorophenyl]carbamate

Conditions
ConditionsYield
In ethanol at 90℃; for 2.5h; Inert atmosphere;100%
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Chemistry

Molecular Structure:

Molecular Formula: C3H8N2O2
Molecular Weight: 104.1078
IUPAC Name: Acetic acid; methanimidamide
Synonyms of Methanimidamide(9CI) (CAS NO.3473-63-0): EINECS 222-442-5 ; Formamidine acetate ; Formamidine, monoacetate ; Formamidinium acetate ; Methanimidamide, monoacetate ; NSC 96608 ; Methanimidamide, acetate (1:1)
CAS NO: 3473-63-0
Classification Code: Pharmaceutical Intermediates
Melting point: 158-161 °C 
H bond acceptors: 2
H bond donors: 1
Polar Surface Area: 26.3 Å2
Flash Point: 40 °C
Enthalpy of Vaporization: 23.7 kJ/mol
Boiling Point: 117.1 °C at 760 mmHg
Vapour Pressure: 13.9 mmHg at 25°C

Uses

  Methanimidamide(9CI) (CAS NO.3473-63-0) is used as synthesis of 4-hydroxy-5-fluoro-uracil.

Safety Profile

Hazard Codes of Methanimidamide(9CI) (CAS NO.3473-63-0): IrritantXi
Risk Statements: 43-36/37/38 
R43: May cause sensitization by skin contact. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-27 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S27: Take off immediately all contaminated clothing.
WGK Germany: 2
F: 3-9-21
HS Code: 29252000

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