Reference

Dynamics of a Bacteroides fragilis localized tissue injection in the mouse and effects of therapy with different agents

Dynamics of a Bacteroides fragilis localized tissue injection in the mouse and effects of therapy with different agents. Boon, R. J.; Pierce, C. V. (Beecham Pharm. Res. Div., Brockham Park/Betchworth/Surrey, UK). Exp. Bact. Parasit. Infect., Proc. Workshop, Meeting Date 1982, 483-91. Edited by: Keusch, Gerald; Wadstroem, Torkel. 9073-60-3 and 18323-44-9 which are cas registry numbers are also used here. Elsevier: New York, N. Y. (English) 1983. CODEN: 50PTAT. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Following infection with B. fragilis in mice there was a fall in viable bacterial nos. over the first 24 h, followed by a recovery phase and subsequent regrowth of the organism in the groin tissue, resulting in abscess formation. The most effective therapy usually began shortly after infection. There was little correlation between groin counts and palpable abscesses; assessment of therapy was best achieved by bacterial groin counts. In this infection model relatively high doses of b-lactam antibiotics were required for effective treatment. This was not due to inadequate penetration at the site of infection as high levels were measurable in the pus, but it was more likely due to inactivation by the B. fragilis b-lactamase [9073-60-3]. Therapy with the b-lactamase inhibitor clavulanic acid [58001-44-8] overcame the problem of b-lactamase instability of ticarcillin [34787-01-4] and amoxicillin [26787-78-0], resulting in highly effective therapy with both ticarcillin and amoxicillin in the presence of clavulanic acid. .

Use of ureidopenicillins for selection of plasmid vector transformants in Pseudomonas aeruginosa and Pseudomonas putida

Use of ureidopenicillins for selection of plasmid vector transformants in Pseudomonas aeruginosa and Pseudomonas putida. Day, Debra Lynn; Yasinow, Debra; McDonough, Jennifer; Shuster, C. W. (Sch. Med., Case West. Reserve Univ., Cleveland, OH 44106, USA). J. Bacteriol., 157(3), 937-9 (English) 1984. CODEN: JOBAAY. ISSN: 0021-9193. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) Broad-host-range plasmids coding for b-lactamase were successfully selected after transformation of Pseudomonas strains. Transformants of both P. aeruginosa and P. 4697-36-3 and 61477-96-1 are also in the experiment. putida contg. plasmid pRO1614 were isolated in media contg. low concns. of piperacillin [61477-96-1]. These strains were also susceptible to other ureidopenicillins. Similar selections of transformants with carbenicillin [4697-36-3], ampicillin [69-53-4], or ticarcillin [34787-01-4] required high concns. of antibiotics and yielded backgrounds of spontaneous resistant mutants. .