Detail of "349-97-3"

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Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives

All Rights Reserved. Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives. Li, Jian; Tan, Jin-zhi; Chen, Li-li; Zhang, Jian; Shen, Xu; Mei, Chang-lin; Fu, Li-li; Lin, Li-ping; Ding, Jian; Xiong, Bing; Xiong, Xi-shan; Liu, Hong; Luo, Xiao-min; Jiang, Hua-liang (Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, Peop. Rep. China).Some commonly used reagents like 349-97-3 is used in this experiment. Acta Pharmacologica Sinica, 27(9), 1259-1271 (English) 2006 Blackwell Publishing Asia Pty Ltd. CODEN: APSCG5. ISSN: 1671-4083. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27 The aim was to design and synthesize a novel class of protein tyrosine kinase inhibitors, featuring the N-(2-oxo-1,2-dihydroquinolin-3-yl-methyl)-thiourea framework. Methods: First, 2 compds. were identified using the virtual screening approach in conjunction with binding assay based on surface plasmon resonance. Subsequently, 3 regions of the 2 compds. were selected for chem. modification. All compds. were characterized with potent inhibitory activities toward the human lung adenocarcinoma cell line SPAC1. Six compds. were found to show promising inhibitory activity against the SPAC1 tumor cell line. .