Detail of "34946-82-2"

Reference

Catalytic role of copper triflate in Lewis acid promoted reactions of diazo compounds

Catalytic role of copper triflate in Lewis acid promoted reactions of diazo compounds. Doyle, Michael P.; Trudell, Mark L. (Dep. Chem., Hope Coll., Holland, MI 49423, USA). J. Org. Chem., 49(7), 1196-9 (English) 1984. CODEN: JOCEAH. ISSN: 0022-3263. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) Cu(O3SCF3)2 (I) is often a superior catalyst for transformations of diazo compds. that are normally promoted by BF3×OEt2. Formal C-O insertion occurs when ortho esters are reacted with diazocarbonyl compds. in the presence of I, although the use of BF3×Et2O provides higher yields of the insertion products. In contrast, the b,g-unsatd. diazo ketone II undergoes intramol. cyclization to produce the corresponding cyclopentenone III in higher yield with I catalysis than with the use of BF3×Et2O. Intramol. cyclopropanation of the g,d-unsatd. diazo ketone IV occurs to give 90% V, when I is used; with BF3×Et2O intramol. cyclization occurs with extensive rearrangement and F- transfer to give VI-VII-VIII. I is unique among transition-metal catalysts that are normally employed for reactions with diazo compds.In this experiment, several chemicals are used like 34946-82-2 and 39163-29-6 in its effectiveness for these transformations. A cycle mechanism involving alkoxy migration, during dediazoniation, and dialkoxycarbenium ions is proposed for these reactions. .

Formal total synthesis of leucascandrolide A

Formal total synthesis of leucascandrolide A. Fettes, Alec; Carreira, Erick M. (Laboratorium fur Organische Chemie ETH Honggerberg, Zurich 8093, Switz.).Several reagents such as 34946-82-2 is used here. Angewandte Chemie, International Edition, 41(21), 4098-4101 (English) 2002 Wiley-VCH Verlag GmbH & Co. KGaA. CODEN: ACIEF5. 5394-63-8 and 123-73-9 which are cas registry numbers are also used here. ISSN: 1433-7851. DOCUMENT TYPE: Journal CA Section: 26 (Biomolecules and Their Synthetic Analogs) The authors have reported an expedient, stereocontrolled formal total synthesis of leucascandrolide A (I, 23 steps longest linear sequence, 2% overall yield). The salient methodol. features of the approach include: the use of a reagent controlled zinc alkynilide addn. to isopropylidene glyceraldehyde; catalytic, enantioselective dienolate aldol addn. to crotanaldehyde; and the use of a selenium-mediated cyclization reaction for the formation of a trans-substituted tetrahydropyran. Moreover, interesting observations concerning hydrogen-bonding effects and conformational flexibility were made in the context of the macrocyclization reaction that may be applicable to other systems. ..