Detail of "35035-05-3"

CAS Number:
35035-05-3
Name:
Piperidinium,3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-, bromide (1:1)
Superlist Name:
Timepidium bromide
Molecular Structure:
Formula:
C17H22 N O S2 . Br
Molecular Weight:
400.43
Synonyms:
Piperidinium,3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-, bromide (9CI);1,1-Dimethyl-5-methoxy-3-(dithien-2-ylmethylene)piperidinium bromide; Mepidium;SA 504; SA 50Y; Sesden; Timepidium bromide
Density:
g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C
Safety:
Poison by intramuscular, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x, SO_x, and Br⁻. Details

Display：

Timepidium bromide

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Intestinal absorption of a new anticholinergic agent, timepidium bromide: Intestinal absorption of a new anticholinergic agent, timepidium bromide. I. Various factors influencing absorption. Meshi, Teruhiko; Tamaki, Hajime (Biol. Chem. Res. Lab., Tanabe Seiyaku Co., Ltd., Toda, Japan). Chem. Pharm. Bull., 26(2), 379-86 (English) 1978. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Various factors influencing intestinal absorption of a quaternary anticholinergic agent, timepidium bromide (I) [35035-05-3] were studied in rats using an in situ intestinal loop technique. Bile, mucin, and intestinal mucous material significantly decreased the amt. of I absorbed from intestinal loops. This decrease was assumed to be due to bonding of I cation to anionic groups of bile constituents, mucin, and intestinal mucous membranes. Gastric juice and HCl significantly increased the absorption of I. Org. acids, such as citric acid [77-92-9], malic acid [6915-15-7], and acetic acid [64-19-7], also increased the absorption of I. The greatest increase in absorption of I was obsd. in the presence of citric acid. Citric acid had this facilitatory effect only when added to the medium in relatively high concns. (0.05 M) and at relatively low pH. However, this increased absorption was shown not to be simply the result of an acidic intestinal environment or irreversible changes in the gut wall.

Chronic toxicity study on a new piperidine derivative, 1,1-dimethyl-5-methoxy-3-(dithien-2-ylmethylene)piperidinium bromide, in dogs: Chronic toxicity study on a new piperidine derivative, 1,1-dimethyl-5-methoxy-3-(dithien-2-ylmethylene)piperidinium bromide, in dogs. Doi, Kunio; Nitta, Shuji; Sakuma, Sadashige; Morita, Takashi; Fujita, Tetsuo; Okaniwa, Azusa (Pharmacol. Res. Lab., Tanabe Seiyaku Co., Ltd., Toda, Japan). Oyo Yakuri, 13(6), 851-62 (English) 1977. CODEN: OYYAA2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Chronic toxicity studies were carried out on the title compd. SA-504 (I) [35035-05-3] in dogs. Oral doses of 50, 30, and 15 mg/kg or i.v. doses of 5, 2, 1, and 0.3 mg/kg were given to animals once a day for about 180 days. In the oral toxicity study, 5 of 14 animals of the 50 mg-group were sacrificed in the course of treatment. Hepatic disorder occurred in dogs receiving an oral dose of 30 mg or more/kg/day. An oral dose of 15 mg/kg/day and i.v. dose of 5, 2, 1, and 0.3 mg/kg/day produced no toxicol. effects.