Detail of "35065-30-6"

Reference

Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract

Polychlorinated biphenyls: congener-specific analysis of a commercial mixture and a human milk extract. Safe, Stephen; Safe, Lorna; Mullin, Michael (Coll. Vet. Med., Texas A and M Univ., College Station, TX 77843, USA). J. Agric. Food Chem., 33(1), 24-9 (English) 1985. CODEN: JAFCAU. ISSN: 0021-8561. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), the 1st congener-specific anal. of a com. PCB prepn., Aroclor 1260 [11096-82-5], and the PCB compn. of a human milk ext. are reported. The anal. indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2,2',3,4',5',6- [38380-04-0], 2,2',4,4',5,5'- [35065-27-1], 2,2',3,4,5,5'- [52712-04-6] and 2,2',3,4,4',5'-hexachlorobiphenyl [35065-28-2] and 2,2',3,3',4,4',5- [35065-30-6], 2,2',3,3',4,5,6'- [38411-25-5], 2,2',3,4,4',5,5'- [35065-29-3], and 2,2',3,4',5,5',6-heptachlorobiphenyl [52663-68-0]. In contrast, the major PCB components of the human milk fraction were the 2,4,4'-tri- [7012-37-5], 2,4,4',5-tetra- [32690-93-0], 2,2',4,4',5-penta- [38380-01-7], 2,3',4,4',5-penta- [31508-00-6], 2,2',3,4,4',5'-hexa-, 2,2',4,4',5,5'-hexa-, 2,2',3,3',4,4',5-hepta-, and 2,2',3,4,4',5,5'-heptachlorobiphenyls. The significance of congener-specific PCB anal. is discussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.

Influence of serum cholesterol and albumin on partitioning of PCB congeners between human serum and adipose tissue

Influence of serum cholesterol and albumin on partitioning of PCB congeners between human serum and adipose tissue. Guo, Y. Leon; Emmett, Edward A.; Pellizzari, Edo D.; Rohde, Charles A. (Cent. Occup. Environ. Health, Johns Hopkins Med. Inst., Research Triangle Park, NC 27709, USA). Toxicol. Appl. Pharmacol., 87(1), 48-56 (English) 1987. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The influence of serum lipids and proteins on partitioning of individual PCB congener peaks between human serum and adipose tissue lipid was assessed using regression anal. Subjects were 55 repair workers who were either currently or previously exposed, and 56 control workers without occupational exposure to PCBs. Seven congeners (2,4,5,4'-tetrachlorobiphenyl (I) [32690-93-0], 2,3,5,2',3',6'-hexachlorobiphenyl [52744-13-5], 2,3,4,2',3',6'-hexachlorobiphenyl [38380-05-1], 2,3,4,2',4',5'-hexachlorobiphenyl [35065-28-2], 3,4,5,3',4'-pentachlorobiphenyl [57465-28-8], 2,3,4,5,2',3',4'-heptachlorobiphenyl [35065-30-6], 2,3,4,5,2',3',4',5'-octachlorobiphenyl [35694-08-7]) which had been quantified in both serum and adipose tissue in at least one-third of the total study population were selected for evaluation. Initially the crude correlations between the serum PCB and certain candidate variables were assessed; more than one congener was correlated with serum cholesterol [57-88-5], albumin, triglycerides, low-d. lipoproteins, very low-d. lipoproteins, age, body fat content, and av. servings of fish per day. Stepwise regression of log serum congener concn. on log adipose congener concn. and these variables was performed. Only cholesterol, albumin, and av. servings of fish per day were significant for at least one congener peak. Congeners behaved in 2 groups, depending on their order of chromatog. elution. For 2,4,5,4'-tetrachlorobiphenyl, 2,3,5,2',3',6'-hexachlorobiphenyl, and 2,3,4,2',3',6'-hexachlorobiphenyl, log serum concn. was not significantly correlated with log adipose congener concn., and there was no consistent pattern for significant candidate variables. For congeners 2,3,4,2',4',5'-hexachlorobiphenyl, 3,4,5,3',4'-pentachlorobiphenyl, 2,3,4,5,2',3',4'-heptachlorobiphenyl, and 2,3,4,5,2',3',4',5'-octachlorobiphenyl, log serum congener concn.There are some commonly used reagents with their cas registry numbers 38380-05-1 and 52744-13-5 in this article. was consistently significantly correlated with log adipose congener concn. and serum cholesterol pos., and with serum albumin neg. For these 4 congeners the explanations of variation in serum congener concn. using adipose congener concn. alone were 3, 23, 20, and 30%, resp., and after adding cholesterol and albumin were 13, 56, 43, and 46%. Thus, serum cholesterol and albumin can influence the distribution or partition of PCBs between serum and adipose tissue. .