Detail of "35109-88-7"

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Nucleosides and nucleotides

Nucleosides and nucleotides. 107. 2-(Cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects. Abiru, Toichi; Miyashita, Takanori; Watanabe, Yohko; Yamaguchi, Toyofumi; Machida, Haruhiko; Matsuda, Akira (Biol. Lab., Yamasa Shoyu Co., Ltd., Chiba 288, Japan). J. Med. Chem., 35(12), 2253-60 (English) 1992. 35109-88-7 are also occured in this study. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Section cross-reference(s): 1 Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effects in spontaneously hypertensive rats (SHR) of a series of 2-(cycloalkylalkynyl)adenosines, e.g. I [R = Ph, CH2CH2Ph, C(OH)Me2, cyclopentyl, cyclohexyl], and their congeners are described. MSBAR of this series of compds. I is discussed, focusing on the length of the alkynyl side chain, and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effects. I had a preferential affinity of for A2 receptors. Of these derivs., 2-(3-cyclopenyl-1-propyn-1-yl)adenosine (II) exhibited the most selective affinity for A2 receptors. In the C-2 binding region of adenosine, compds. often have potent and/or selective A2 activity from introduction of an acetylenic group at the C-2 position followed by one methylene residue further followed by a hydrophobic substituent such as a cycloalkyl ring at the terminal position of the alkynyl side chain. I.v. injection of II up to 100 mg/kg had a potent hypotensive effect without a marked decrease in heart rate in anesthetized SHR. These compds. caused a marked bradycardia upon i.v. administration in anesthetized SHR. There are some commonly used reagents like 35109-88-7 in this article. Oral administration of II (0.1-1 mg/kg) had a potent and long-lasting antihypertensive effect in conscious SHR. ..

Nucleosides and nucleotides

Nucleosides and nucleotides. 107. 2-(Cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects. Abiru, Toichi; Miyashita, Takanori; Watanabe, Yohko; Yamaguchi, Toyofumi; Machida, Haruhiko; Matsuda, Akira (Biol. Lab., Yamasa Shoyu Co., Ltd., Chiba 288, Japan). J. Med. Chem., 35(12), 2253-60 (English) 1992. 35109-88-7 are also occured in this study. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Section cross-reference(s): 1 Adenosine receptor-binding profiles in rat brain tissues and antihypertensive effects in spontaneously hypertensive rats (SHR) of a series of 2-(cycloalkylalkynyl)adenosines, e.g. I [R = Ph, CH2CH2Ph, C(OH)Me2, cyclopentyl, cyclohexyl], and their congeners are described. MSBAR of this series of compds. I is discussed, focusing on the length of the alkynyl side chain, and bulkiness of the terminal cycloalkyl substituents in terms of binding activity and cardiovascular effects. I had a preferential affinity of for A2 receptors. Of these derivs., 2-(3-cyclopenyl-1-propyn-1-yl)adenosine (II) exhibited the most selective affinity for A2 receptors. In the C-2 binding region of adenosine, compds. often have potent and/or selective A2 activity from introduction of an acetylenic group at the C-2 position followed by one methylene residue further followed by a hydrophobic substituent such as a cycloalkyl ring at the terminal position of the alkynyl side chain. I.v. injection of II up to 100 mg/kg had a potent hypotensive effect without a marked decrease in heart rate in anesthetized SHR. These compds. caused a marked bradycardia upon i.v. administration in anesthetized SHR. There are some commonly used reagents like 35109-88-7 in this article. Oral administration of II (0.1-1 mg/kg) had a potent and long-lasting antihypertensive effect in conscious SHR. ..