Detail of "3528-58-3"

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Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction

Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction. Yu, Guixue; Mason, Helen; Wu, Ximao; Wang, Jian; Chong, Saeho; Beyer, Bruce; Henwood, Andrew; Pongrac, Ronald; Seliger, Laurie; He, Bin; Normandin, Diane; Ferrer, Pam; Zhang, Rongan; Adam, Leonard; Humphrey, William G.; Krupinski, John; Macor, John E. ( Discovery Chemistry, Drug Metabolism and Pharmacokinetics, Princeton, NJ 08543-5400, USA). Journal of Medicinal Chemistry, 46(4), 457-460 (English) 2003 American Chemical Society. CODEN: JMCMAR. 3528-58-3 which is the cas registry number of one of substances is just one of reagents here. ISSN: 0022-2623. 3528-58-3 which is the cas registry number is also used here. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Novel pyrazolopyridopyridazines, e.g. I, have been prepd. as potent and selective PDE5 inhibitors. I has been identified as a more potent and selective PDE5 inhibitor than sildenafil. It is as efficacious as sildenafil in in vitro and in vivo PDE5 inhibition models, and it is orally bioavailable in rats and dogs. The superior isoenzyme selectivity of I is expected to exert less adverse effects in humans when used for erectile dysfunction treatment. ..

Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction

Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction. Yu, Guixue; Mason, Helen; Wu, Ximao; Wang, Jian; Chong, Saeho; Beyer, Bruce; Henwood, Andrew; Pongrac, Ronald; Seliger, Laurie; He, Bin; Normandin, Diane; Ferrer, Pam; Zhang, Rongan; Adam, Leonard; Humphrey, William G.; Krupinski, John; Macor, John E. ( Discovery Chemistry, Drug Metabolism and Pharmacokinetics, Princeton, NJ 08543-5400, USA). Journal of Medicinal Chemistry, 46(4), 457-460 (English) 2003 American Chemical Society. CODEN: JMCMAR. 3528-58-3 which is the cas registry number of one of substances is just one of reagents here. ISSN: 0022-2623. 3528-58-3 which is the cas registry number is also used here. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Novel pyrazolopyridopyridazines, e.g. I, have been prepd. as potent and selective PDE5 inhibitors. I has been identified as a more potent and selective PDE5 inhibitor than sildenafil. It is as efficacious as sildenafil in in vitro and in vivo PDE5 inhibition models, and it is orally bioavailable in rats and dogs. The superior isoenzyme selectivity of I is expected to exert less adverse effects in humans when used for erectile dysfunction treatment. ..