Detail of "35322-07-7"

CAS Number:
35322-07-7
Name:
2H-1,4-Benzodiazepin-2-one,7-chloro-1-[(dimethylphosphinyl)methyl]-1,3-dihydro-5-phenyl-
Molecular Structure:
Formula:
C18H18 Cl N2 O2 P
Molecular Weight:
360.80
Synonyms:
Fosazepam;HR 930; HR 930 (psychotropic)
Density:
1.31g/cm³
Boiling Point:
638°Cat760mmHg
Flash Point:
339.6°C
Safety:
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Cl⁻, PO_x, and NO_x. See also DIAZEPAM. Details

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Evaluation of the effect of fosazepam (a new benzodiazepine), nitrazepam and placebo on sleep patterns in normal subjects: Evaluation of the effect of fosazepam (a new benzodiazepine), nitrazepam and placebo on sleep patterns in normal subjects. Risberg, Ann Marie; Henricsson, S.; Ingvar, D. H. (Dep. Clin. Neurophysiol., Univ. Hosp. Lund, Lund, Swed.). Eur. J. Clin. Pharmacol., 12(2), 105-9 (English) 1977. CODEN: EJCPAS. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The nocturnal sleep of eight healthy young volunteers was studied after placebo, fosazepam (I) [35322-07-7] (100 mg) and nitrazepam [146-22-5] (10 mg). Overall results were very similar after the 2 drugs. During drug periods, there was less of sleep stages I, III + IV, and rapid eye movement (REM) compensated by an increase in stage II. The decrease in slow-wave sleep (SWS) (III + IV) persisted during the withdrawal periods. There was also an increase in stage I during I withdrawal, whereas the percentage of other sleep stages returned to normal. Sleep quality was reported to be slightly better and morning drowsiness, as well as hangover effects, were said to be less pronounced after I than after nitrazepam.

A placebo-controlled comparison of the sedative properties of three benzodiazepines, lorazepam, flunitrazepam and fosazepam: A placebo-controlled comparison of the sedative properties of three benzodiazepines, lorazepam, flunitrazepam and fosazepam. Dundee, J. W.; Johnston, H. M. L.; Lilburn, J. K.; Nair, S. G.; Scott, M. G. (Dep. Anaesth., Queen's Univ., Belfast, N. Ire.). Br. J. Clin. Pharmacol., 4(6), 706-8 (English) 1977. CODEN: BCPHBM. ISSN: 0306-5251. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Of the 3 benzodiazepines tested in women, flunitrazepam (I) [1622-62-4] (1 or 2 mg) produced the most effective sedation and the lowest incidence of restlessness and apprehension. Lorazepam (II) [846-49-1] (2.5 or 5 mg) had a slower onset of action than that of I and produced comparable sedation only at the higher dose. Fosazepam (III) [35322-07-7](40, 60, or 80 mg) was most effective at 60 mg with restlessness occurring at 80 mg; III did not seem to have any advantages over I and II. Time-course data are given also.