Reference

The in vivo exposure to plant flavonols

The in vivo exposure to plant flavonols. Influence on frequencies of micronuclei in mouse erythrocytes and sister-chromatid exchange in rabbit lymphocytes. MacGregor, James T.; Wehr, Carol M.Several substances are used for example 117-39-5 which is its cas registry number.; Manners, Gary D.; Jurd, Leonard; Minkler, Jason L.; Carrano, Anthony V. (Western Reg. Res. Cent., U.S. Dep. Agric., Berkeley, CA 94710, USA). Mutat. Res., 124(3-4), 255-70 (English) 1983. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) No consistent increases in the micronucleus frequency were obsd. in bone marrow or peripheral blood erythrocytes from mice treated with quercetin (I) [117-39-5], rhamnetin [90-19-7],neohesperidin dihydrochalcone [20702-77-6], or hesperetin dihydrochalcone [35400-60-3] under various exposure and sampling conditions. Over the dose range of 100-1000 mg/kg, I failed to increase significantly erythrocyte micronucleus frequencies either in bone marrow of male mice at 6 h after the 2nd of 2 i.p. or oral doses given 24 h apart, or at 48, 96, or 192 h after a single i.p. or oral dose, or in peripheral blood of male or female mice sampled for 7 consecutive days following a single i.p. dose. Feeding 5 or 10% I for 8 days also failed to increase the micronucleus frequency in bone marrow erythrocytes of female or male mice. Hesperetin dihydrochalcone and neohesperidin dihydrochalcone, at oral doses of 100-1000 mg/kg, did not increase the micronucleus frequency in bone marrow erythrocytes 6 h after the 2nd doses 24 h apart, nor did rhamnetin at 48 or 96 h after a single i.p. dose of 100 mg/kg. Galangin [548-83-4], in contrast, did increase the micronucleus frequency in bone marrow and blood erythrocytes under certain conditions, but the largest increases were only 2-3-times control values and these were obsd. at highly toxic doses. Rabbits given up to 250 mg/kg I i.p. showed no treatment-related increase in the sister chromatid-exchange frequency in peripheral blood lymphocytes sampled at 1 and 7 days after treatment. These results fail to confirm published data which report a markedly increased frequency of micronuclei in bone marrow erythrocytes from I-treated mice, show no I-related alterations in the sister chromatid-exchange frequency in rabbit lymphocytes, and indicate that clastogenesis in bone marrow erythoblasts due to oral or i.p. administration of the flavonols studied is at most very weak. .

Studies on the structure-taste relationships (1)

Studies on the structure-taste relationships (1). Quantitative analysis of the molecular model of dihydrochalcone. Lah, Myoung Soo; Lim, Byung Chul; Koo, Chung Hoe; Shin, Whanchul (Coll. Nat. Sci., Seoul Natl. Univ.There are some reagents like 35400-60-3 is used in this study., Seoul 151, S. Korea). Taehan Hwahakhoe Chi, 30(2), 259-62 (English) 1986. CODEN: DHWHAB. ISSN: 0418-2472. DOCUMENT TYPE: Journal CA Section: 26 (Biomolecules and Their Synthetic Analogs) Section cross-reference(s): 13, 22 Hesperetin dihydrochalcone (I), a representative of dihydrochalcone sweeteners, was examd. with the computer program ROTOR by rotating 3 torsion angles. Among the conformations allowed, a bent form similar to that of phylloducin could not be found. The extended form of I appeared to be the active conformation. These results were discussed with respect to sweetness and receptor interactions. .