Reference

Pharmaceutical products for oral administration

Pharmaceutical products for oral administration. Kobayashi, Toshiyuki; Okada, Akio; Mayama, Takeshi; Okada, Akira (Meiji Confectionary Co., Ltd., Japan). Belg. BE 838239 28 May 1976, 14 pp. (Unavailable). (Belgium). CODEN: BEXXAL. CLASS: IC: A61K. PRIORITY: JP 75-117513 29 Sep 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Palatable compns. contg. bitter active ingredients are prepd. by dissolving a substance which conceals the bitterness in a solvent contg. the active ingredient, and adding anhyd. silicic acid to form a powder. Granules are then made using a fluidized bed. For example, granules were prepd. from a 2 L CH2Cl2 soln. contg. midecamycin [35457-80-8] 1 kg to which ethyl cellulose [9004-57-3], 1 kg, was added. Sufficient arom. granules, comprising mannitol [69-65-8]-Na saccharin [128-44-9] ( by wt.In this experiment, several chemicals are used like 56-75-7 and 9005-65-6 ), were then mixed in to produce a prepn. contg. 100 mg midecamycin/g. .

Effects of macrolide antibiotics on barbiturate sleeping time in mice

Effects of macrolide antibiotics on barbiturate sleeping time in mice.Some chemicals with cas registry numbers like 76-74-4 and 8025-81-8 are also used. Descotes, J.; Evreux, J. Cl. (Lab. Pharmacol., Fac. Med. Alexis Carrel, Lyon F-69008, Fr.). Experientia, 39(12), 1389-90 (English) 1983. CODEN: EXPEAM. ISSN: 0014-4754. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Triacetyloleandomycin [2751-09-9] and josamycin [16846-24-5], when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg/kg over 3 days, increased barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate [1264-62-6], erythromycin propionate [134-36-1], midecamycin [35457-80-8], and spiramycin [8025-81-8] were devoid of any such activity under the same conditions. The relationship of these results to the effect of macrolide antibiotics on drug-metabolizing enzymes and their drug-drug interactions are discussed. .