Detail of "35604-67-2"

CAS Number:
35604-67-2
Name:
Morpholine,2-[(2-ethoxyphenoxy)methyl]-, hydrochloride (1:1)
Superlist Name:
Viloxazine hydrochloride
Molecular Structure:
Formula:
C13H19 N O3 . Cl H
Molecular Weight:
273.79
Synonyms:
Morpholine,2-[(2-ethoxyphenoxy)methyl]-, hydrochloride (9CI); 2-[(2-Ethoxyphenoxy)methyl]morpholiniumchloride; Catatrol; ICI 58834; Vicilan; Viloxazin hydrochloride; Viloxazinehydrochloride; Vivalan; Vivarint; Vivilan
EINECS:
252-638-6
Density:
1.061g/cm³
Boiling Point:
350.5°Cat760mmHg
Flash Point:
144.3°C
Safety:
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by ingestion: hallucinations, distorted perceptions and convulsions or effect on seizure threshold. When heated to decomposition it emits very toxic fumes of NO_x and HCl. Used as an antidepressant. See also VILOXAZINE. Details

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Effects of viloxazine on cortical neuron responses to monoamines and acetylcholine: Effects of viloxazine on cortical neuron responses to monoamines and acetylcholine. Jones, R. S. G.; Roberts, M. H. T. (Dep. Physiol., Univ. Coll., Cardiff, Wales). Br. J. Pharmacol., 59(3), 460P (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Repeated responses to noradrenaline (I) [51-41-2], 5-hydroxytryptamine (II) [50-67-9], and acetylcholine (III) [51-84-3], of single neurons in the somatosensory cortex of anesthetized rats, were compared before and after the brief application of viloxazine-HCl (IV) [35604-67-2] (20-100 nA, 20-50 s); after application of IV, responses to I, II, and III were either potentiated or reduced in size. Both effects often occurred in the same study, redn. of response always preceding potentiation; redn. of response occurred during the first 5-10 min after IV application with potentiation occurring over the next 15-40 min. The potentiation of I and II responses by IV is probably caused by IV blockage of amine uptake mechanisms; the redn. of I and II responses possibly indicates that IV has adrenolytic and anti-II properties. IV may block central nervous system receptors for III or may affect III inactivation.

Non-metabolite residues of ICI 58,834 (viloxazine): Non-metabolite residues of ICI 58,834 (viloxazine). Studies with [14C]morphine, [14C]morpholine, [14C]ethanolamine and [14C]glyoxylate. Rhodes, C.; Case, D. E. (Pharm. Div., Imp. Chem. Ind. Ltd., Macclesfield, Engl.). Xenobiotica, 7(1-2), 112 (English) 1977. CODEN: XENOBH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The persistence of low levels of radioactivity in dog whole blood was obtained after administration of 14C-labeled morpholine (I) [110-91-8], glyoxylate [298-12-4], or ethanolamine (II) [141-43-5] (t1/2 22-8, 22-5, and 19 days resp.). Half lives detd. from plasma rather than whole bloodd levels were lower (I, 13; glyoxylate 8.5-9.5; ICI 58,834 [35604-67-2] 7 days), suggesting a general labeling of blood components. Excretion of radioactivity as a percentage of the dose in dog urine was II 11, glyoxylate 35-41, I 81-5, and ICI 58,834 91-3%. After 24 h the total blood radioactivity as a percentage of the dose was II 1.69, glyoxylate 2.07-3.93, I 0.31-0.63, and ICI 58,834 0.68%. The similarities in the behavior of these compds. suggests that a small percentage of tetrahydrooxazine rings of ICI 58,834 and I is converted to common, low-mol.-wt. fragments which are then incorporated into tissue components.