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CAS No.: | 356560-84-4 |
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Name: | 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C14H10N4O2 |
Molecular Weight: | 266.259 |
Synonyms: | 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione;QC-1211;1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl); |
EINECS: | 1308068-626-2 |
Density: | 1.39±0.1 g/cm3(Predicted) |
PSA: | 77.22000 |
LogP: | 1.49830 |
1-(6-methylpyridin-2-yl)-2-([1,2,4]triazolo[1,5-a]pyridin-6-yl)ethanone
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
Conditions | Yield |
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With hydrogen bromide; dimethyl sulfoxide at 60 - 70℃; for 2h; | 92% |
With water; hydrogen bromide In dimethyl sulfoxide at 60 - 70℃; for 2h; |
6-methyl-2-pyridinecarboxaldehyde
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: ziconium(IV) oxychloride octahydrate / 1 h / 20 °C 2.1: caesium carbonate / isopropyl alcohol; tetrahydrofuran / 20 °C 2.2: 1 h 2.3: pH 7 - 8 3.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C View Scheme |
diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: caesium carbonate / isopropyl alcohol; tetrahydrofuran / 20 °C 1.2: 1 h 1.3: pH 7 - 8 2.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C View Scheme |
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
dimethoxyacetaldehyde
6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine
Conditions | Yield |
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With ammonium acetate In methanol; tert-butyl methyl ether; water at 20℃; for 4h; | 83% |
With ammonium acetate In methanol; tert-butyl methyl ether; water at 20℃; for 4h; | 83% |
Stage #1: 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione; dimethoxyacetaldehyde With ammonium acetate In methanol; tert-butyl methyl ether; water at 20℃; for 3h; Stage #2: With sodium hydrogencarbonate In methanol; tert-butyl methyl ether; water pH=8; | 78% |
N-phthalimidyl-2-aminoacetaldehyde
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
2-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)isoindoline-1,3-dione
Conditions | Yield |
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With ammonium acetate In methanol; tert-butyl methyl ether at 20 - 50℃; for 10h; | 67% |
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
2-phenoxyethanal
6-(5-(6-methylpyridin-2-yl)-2-(phenoxymethyl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine
Conditions | Yield |
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With ammonium acetate In methanol; tert-butyl methyl ether at 20℃; for 1.16667h; Inert atmosphere; | 56% |
With ammonium acetate In methanol; tert-butyl methyl ether at 20℃; Inert atmosphere; | 56% |
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
2-(phenylthio)acetaldehyde
6-(5-(6-methylpyridin-2-yl)-2-((phenylthio)methyl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine
Conditions | Yield |
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With ammonium acetate In methanol; tert-butyl methyl ether at 20℃; for 1.16667h; Inert atmosphere; | 38% |
With ammonium acetate In methanol; tert-butyl methyl ether at 20℃; Inert atmosphere; | 38% |
6,7-dimethoxy-3,4-dihydro-isoquinoline
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
Conditions | Yield |
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With ammonium acetate; acetic acid In tert-butyl methyl ether Heating / reflux; | 37% |
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
3-cyanophenyl-1-acetaldehyde
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile
Conditions | Yield |
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Stage #1: 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione; 3-cyanophenyl-1-acetaldehyde With ammonium acetate In methanol; tert-butyl methyl ether at 20℃; for 1.5h; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In methanol; tert-butyl methyl ether; water pH=8; Inert atmosphere; | 33% |
1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
2-((2-fluorophenyl)(methyl)amino)acetaldehyde
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoro-N-methylaniline
Conditions | Yield |
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Stage #1: 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione; 2-((2-fluorophenyl)(methyl)amino)acetaldehyde With ammonium acetate In methanol; tert-butyl methyl ether at 20℃; for 2h; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In methanol; tert-butyl methyl ether; water pH=8; Inert atmosphere; | 32% |