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357-70-0

Basic Information
CAS No.: 357-70-0
Name: Galanthamine
Article Data: 44
Molecular Structure:
Molecular Structure of 357-70-0 (Galanthamine)
Formula: C17H21NO3
Molecular Weight: 287.359
Synonyms: 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl- (7CI);Galanthamine (6CI,8CI);(-)-Galantamine;(-)-Galanthamine;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol,4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, [4aS-(4aa,6b,8aR*)]-;BRN 0093736;Galantamin;Galantamina;Jilkon;Lycoremin;Lycoremine;NSC 100058;(+)Galanthamine;736-79-8;
EINECS: 609-175-3
Density: 1.28 g/cm3
Melting Point: 119-121 °C
Boiling Point: 439.3 °C at 760 mmHg
Flash Point: 219.5 °C
Appearance: Off-white sSolid
PSA: 41.93000
LogP: 1.78820
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    Address:No.10048, xiangjiang centry bulding ,kaifu district ,changsha city ,Hunan

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  • Galanthamine

  • Casno:

    357-70-0

    Galanthamine

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

    SAGECHEM is a chemical R&D, manufacturing and distribution company since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and

  •  SAGECHEM LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-86818502

    Address:5Fl. 501Room, Tower A, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China

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  • Galantamin

  • Casno:

    357-70-0

    Galantamin

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 1.5-1.5

    1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

    KAISA GROUP INC.is the enterprise which is specialize in manfacturing and exporting avariety of Chemical in China. We have the strong economic base and comprehensive technology.We

  •  KAISA GROUP INC

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:15131197030

    Address:1312 17th Street Suite 1402 Denver CO 80202

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  • Lycoremine CAS 357-70-0 Galanthamine Hydrobromide for Alzheimer′s Disease Treatment

  • Casno:

    357-70-0

    Lycoremine CAS 357-70-0 Galanthamine Hydrobromide for Alzheimer′s Disease Treatment

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

    We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production in China for chemicals cus

  •  Bluecrystal chem-union

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-1895157

    Address:Liang Xi Qu

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Specification

The Galantamine is an organic compound with the formula C17H21NO3. The systematic name of this chemical is galanthamine. With the CAS registry number 357-70-0, it is also named as 3,4-Dihydrogalanthamine. The product's categories are All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is an off-white solid, which is used for the treatment of mild to moderate Alzheimer's disease and various memory impairments. Galantamine is indicated for mild to moderate Vascular Dementia and Alzheimer.

Physical properties about Galantamine are: (1)ACD/LogP: 1.75; (2)ACD/LogD (pH 5.5): -0.59; (3)ACD/LogD (pH 7.4): 1.12; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 2.94; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 49.83; (8)#H bond acceptors: 4; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 30.93 Å2; (12)Index of Refraction: 1.636; (13)Molar Refractivity: 80.31 cm3; (14)Molar Volume: 223.9 cm3; (15)Polarizability: 31.83×10-24cm3; (16)Surface Tension: 56.6 dyne/cm; (17)Density: 1.28 g/cm3; (18)Flash Point: 219.5 °C; (19)Enthalpy of Vaporization: 73.39 kJ/mol; (20)Boiling Point: 439.3 °C at 760 mmHg; (21)Vapour Pressure: 1.71E-08 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c2c1O[C@H]4C[C@@H](O)/C=C\[C@@]43c1c(cc2)CN(C)CC3)C
(2)InChI: InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(3)InChIKey: ASUTZQLVASHGKV-JDFRZJQEBY
(4)Std. InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
(5)Std. InChIKey: ASUTZQLVASHGKV-JDFRZJQESA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 10mg/kg (10mg/kg)   Journal of Medicinal Chemistry. Vol. 37, Pg. 689, 1994.
mouse LD50 subcutaneous 14mg/kg (14mg/kg)   United States Patent Document. Vol. #4550113,
rat LD50 intraperitoneal 22900mg/kg (22900mg/kg)   United States Patent Document. Vol. #5177082,

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