CAS No.35711-34-3,Tolmetin sodium Suppliers

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Basic Information

Molecular Structure:
CAS No.:	35711-34-3
Name:	Tolmetin sodium
Article Data:	4

Formula:	C15H15 N O3 . Na
Molecular Weight:	279.271
Synonyms:	1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (9CI); Sodium1-methyl-5-p-toluoylpyrrole-2-acetate; Sodium tolmetin; Tolectin; Tolmetinsodium; Tolmetin sodium salt
EINECS:	252-687-3
Density:	1.18g/cm³
Melting Point:	155-157oC (DECOMPOSES)
Boiling Point:	483.2 °C at 760 mmHg
Flash Point:	246 °C
Safety:	Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, blood pressure depression, eye irritation, hallucinations or distorted perceptions, liver function impairment, shock, spinal cord effects, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Na₂O.
PSA:	62.13000
LogP:	0.85690

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Chemistry

Empirical Formula of Tolmetin sodium (CAS NO.35711-34-3): C₁₅H₁₄NNaO₃
Molecular Weight: 279.2663
EINECS: 252-687-3
Flash Point: 246 °C
Enthalpy of Vaporization: 78.81 kJ/mol
Boiling Point: 483.2 °C at 760 mmHg
Vapour Pressure: 3.79E-10 mmHg at 25 °C
Structure of Tolmetin sodium (CAS NO.35711-34-3):

H-Bond Donor: 0
H-Bond Acceptor: 3
IUPAC Name of Tolmetin sodium (CAS NO.35711-34-3): Sodium 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-].[Na+]
InChI: InChI=1S/C15H15NO3.Na/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;/h3-8H,9H2,1-2H3,(H,17,18);/q;+1/p-1
InChIKey: QGUALMNFRILWRA-UHFFFAOYSA-M

Uses

Tolmetin sodium (CAS NO.35711-34-3) has been used as an antipyretic analgesic.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	2520mg/kg/8W- (2520mg/kg)	BLOOD: THROMBOCYTOPENIA	Arthritis and Rheumatism. Vol. 25, Pg. 1144, 1982.
dog	LD50	oral	> 800mg/kg (800mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
hamster	LD50	oral	1584mg/kg (1584mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
human	TDLo	oral	8mg/kg (8mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: SHOCK	JAMA, Journal of the American Medical Association. Vol. 240, Pg. 246, 1978.
man	TDLo	oral	538mg/kg/61D- (538mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1263, 1980.
mouse	LD50	intraperitoneal	690mg/kg (690mg/kg)		Drugs in Japan Vol. 6, Pg. 532, 1982.
mouse	LD50	intravenous	> 622mg/kg (622mg/kg)		Drugs in Japan Vol. 6, Pg. 532, 1982.
mouse	LD50	oral	899mg/kg (899mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
mouse	LD50	subcutaneous	670mg/kg (670mg/kg)		Drugs in Japan Vol. 6, Pg. 532, 1982.
rat	LD50	intraperitoneal	770mg/kg (770mg/kg)		Drugs in Japan Vol. 6, Pg. 532, 1982.
rat	LD50	intravenous	> 724mg/kg (724mg/kg)		Drugs in Japan Vol. 6, Pg. 532, 1982.
rat	LD50	oral	914mg/kg (914mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
rat	LD50	subcutaneous	1050mg/kg (1050mg/kg)		Drugs in Japan Vol. 6, Pg. 532, 1982.
women	TDLo	oral	8mg/kg (8mg/kg)	SPINAL CORD: MENINGEAL CHANGES SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LIVER: LIVER FUNCTION TESTS IMPAIRED	JAMA, Journal of the American Medical Association. Vol. 245, Pg. 67, 1981.

Safety Profile

Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, blood pressure depression, eye irritation, hallucinations or distorted perceptions, liver function impairment, shock, spinal cord effects, thrombocytopenia. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Na₂O.

Specification

Tolmetin sodium ,its cas register number is 35711-34-3. It also can be called Natrium-{1-methyl-5-[(4-methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetat ; 1H-pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt (1:1) ; Tolectin and Sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate .