Detail of "3575-32-4"

Reference

Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases

Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases. Manley, Paul W.; Breitenstein, Werner; Brueggen, Josef; Cowan-Jacob, Sandra W.; Furet, Pascal; Mestan, Juergen; Meyer, Thomas (Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel CH-4002, Switz.Chemicals with cas numbers 3575-32-4 and 108-42-9 also play role.). Bioorganic & Medicinal Chemistry Letters, 14(23), 5793-5797 (English) 2004 Elsevier B.V. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The constitutively active Abl kinase activity of the Bcr-Abl oncoprotein is causative for chronic myelogenous leukemia. Urea derivs., structurally related to the therapeutic agent STI571, have been identified, which potently inhibit the tyrosine kinase activity of recombinant Abl. In particular a dimethylamino-aniline deriv. (18) inhibited c-Abl transphosphorylation with an IC50 value of 56 nM. Although this activity was not translated into cellular activity against the constitutively activated oncogenic Bcr-Abl, a no. of compds. from this series potently inhibited cellular PDGFR autophosphorylation. It was also possible to differentiate between c-Abl and PDGFR kinase inhibition, with compd. 22 being selective towards Abl and 23 selective for PDGFR. .

Simultaneous laser thermal lens spectrometric determination of trace platinum and palladium in an aqueous solution

Simultaneous laser thermal lens spectrometric determination of trace platinum and palladium in an aqueous solution. Zhang, Xiao-Ling; Yan, Hong-Tao (Department of Chemistry, Northwest University, Xi'an 710069, Peop. Rep. China). Chinese Journal of Chemistry, 20(10), 1055-1059 (English) 2002 Science Press. CODEN: CJOCEV. ISSN: 1001-604X. DOCUMENT TYPE: Journal CA Section: 79 (Inorganic Analytical Chemistry) Section cross-reference(s): 56, 67 A selective and sensitive method for detn. of platinum and palladium(II) in an aq. soln. simultaneously by laser thermal lens spectrometry, based on the complex reaction of 2-(3,5-dichloropyridylazo)-5-dimethylaminoaniline (3,5-di-Cl-PADMA) with platinum and palladium, was developed. The palladium complex can be formed at room temp., while the platinum complex can be only formed after being heated in a boiling water bath. By this difference of reaction temp. and the characteristic of the complexes mentioned above, the method for simultaneous detn. of platinum and palladium was established in an aq. soln.Several substances with their cas registry numbers 7440-06-4 and 3575-32-4 may be metioned in this study. without a pre-sepn. The dynamic linear ranges of detn. for platinum and palladium are 0.005-0.04 mg/mL and 0.005-0.25 mg/mL resp., and that the detection limits are both 0.002 mg/mL. The method was applied to the detn. of platinum and palladium simultaneously in alloy and catalyst samples with satisfactory results. .