Products Categories
CAS No.: | 3577-01-3 |
---|---|
Name: | cefaloglycin |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C18H19 N3 O6 S |
Molecular Weight: | 405.431 |
Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-7-[(aminophenylacetyl)amino]-8-oxo-, [6R-[6a,7b(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-7-[[(2R)-aminophenylacetyl]amino]-8-oxo-, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-(2-amino-2-phenylacetamido)-3-(hydroxymethyl)-8-oxo-, acetate (ester), D-(8CI); 7-(2-D-a-Aminophenylacetamido)cephalosporanicacid; Cefaloglycin; Cefaloglycine; Cephaloglycin; Cephaloglycine;D-(-)-Cephaloglycin; D-Cephaloglycine; Kafocin; Kefglycin; Lilly 39435 |
Density: | 1.52g/cm3 |
Melting Point: | 236.5°C (rough estimate) |
Boiling Point: | 761.8°C at 760 mmHg |
Flash Point: | 414.5°C |
Solubility: | 10.5g/L(25 oC) |
Hazard Symbols: | Xn |
Risk Codes: | 42/43 |
Safety: | Moderately toxic by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. |
PSA: | 164.33000 |
LogP: | 1.01720 |
(6R)-3-acetoxymethyl-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cephaloglycin
Conditions | Yield |
---|---|
(i) CF3CO2H, (ii) ion exchange resin - form>; Multistep reaction; |
Conditions | Yield |
---|---|
at 30℃; for 3h; Pseudomonas melanogenum KY 3987 and KY 8540; Yield given; |
D-phenylglycine methyl ester hydrochloride
7-Aminocephalosporanic acid
cephaloglycin
Conditions | Yield |
---|---|
With potassium phosphate; Pseudomonas melanogenum KY 8541 at 30℃; pH=6.5; |
Boc-D-Phg-OH
cephaloglycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (i) Et3N, (ii) iBuOCOCl, (iii) /BRN= 5406532/ 2: (i) CF3CO2H, (ii) ion exchange resin - form> View Scheme |
N,O-bis-(trimethylsilyl)-acetamide
cephaloglycin
Conditions | Yield |
---|---|
In dichloromethane; ethyl acetate | 55% |
Conditions | Yield |
---|---|
26% |
1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
cephaloglycin
isobutyl chloroformate
butan-1-ol
(6R)-3-acetoxymethyl-8-oxo-7t-[(R)-2-(1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino)-2-phenyl-acetylamino]-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With magnesium sulfate; triethylamine In N-methyl-acetamide; diethyl ether; dichloromethane; water |
5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
cephaloglycin
isobutyl chloroformate
butan-1-ol
(6R)-3-acetoxymethyl-7t-[(R)-2-((Ξ)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino)-2-phenyl-acetylamino]-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With magnesium sulfate; triethylamine In N-methyl-acetamide; diethyl ether; water |
cephaloglycin
8-(4-formyl-1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
isobutyl chloroformate
butan-1-ol
(6R)-3-acetoxymethyl-7t-{(R)-2-[8-(4-formyl-piperazin-1-yl)-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carbonylamino]-2-phenyl-acetylamino}-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Conditions | Yield |
---|---|
With magnesium sulfate; triethylamine In N-methyl-acetamide; diethyl ether; water |
Conditions | Yield |
---|---|
With dimethyl sulfoxide In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl acetamide; ethyl acetate |
Chemistry informtion about Cefaloglycin (CAS NO.3577-01-3) is:
IUPAC Name: (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-Amino-2-Phenylacetyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
Synonyms: Cefaloglycin ; Cephaloglycin ; (6r,7r)-7-[(R)-2-Amino-2-Phenylacetylamino]-3-(Acetoxymethyl)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid ; Cephaloglycin(Anhydrous) ; Kafocin ; Kefglycin ; Lilly-39435
MF: C18H19N3O6S
MW: 0
EINECS: 222-696-7
Density: 1.52 g/cm3
Flash Point: 414.5 °C
Boiling Point: 761.8 °C at 760 mmHg
Vapour Pressure: 2.14E-24 mmHg at 25°C
Enthalpy of Vaporization: 116.41 kJ/mol
Following is the molecular structure of Cefaloglycin (CAS NO.3577-01-3) is:
Preparation Products is Cefpimizole .
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1030mg/kg (1030mg/kg) | kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" | Chemotherapy Vol. 18, Pg. 22, 1970. |
mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | liver: other changes | Chemotherapy Vol. 18, Pg. 22, 1970. |
mouse | LD50 | subcutaneous | 3700mg/kg (3700mg/kg) | kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" | Chemotherapy Vol. 18, Pg. 22, 1970. |
rat | LD50 | intraperitoneal | 1300mg/kg (1300mg/kg) | kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" | Chemotherapy Vol. 18, Pg. 22, 1970. |
rat | LD50 | oral | > 10gm/kg (10000mg/kg) | liver: other changes | Chemotherapy Vol. 18, Pg. 22, 1970. |
rat | LD50 | subcutaneous | 2800mg/kg (2800mg/kg) | kidney, ureter, and bladder: "changes in tubules (including acute renal failure, acute tubular necrosis)" | Chemotherapy Vol. 18, Pg. 22, 1970. |
Moderately toxic by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Cefaloglycin (CAS NO.3577-01-3) is a first generation cephalosporin antibiotic.