Detail of "359-83-1"

Reference

Effects of concomitant pentazocine and tripelennamine on brain-stimulation reward

Effects of concomitant pentazocine and tripelennamine on brain-stimulation reward. Unterwald, Ellen M.; Kornetsky, Conan (Sch. Med., Boston Univ., Boston, MA 02118, USA). Pharmacol., Biochem. Behav., 21(6), 961-4 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 Reinforcing thresholds for self-stimulation behavior to the medial forebrain bundle were detd. in rats by means of a rate-free psychophys. method. The acute administration of either pentazocine [359-83-1] or tripelennamine [91-81-6] caused a small but significant lowering of the reward threshold. Combined administration of an ineffective dose of tripelennamine with various doses of pentazocine resulted in a potentiation of this lowering effect. The widespread abuse of the combination of pentazocine and tripelennamine may be due to a pharmacol. potentiation rather than just a summation of their 2 effects.

Characterization of the interaction of pentazocine and tripelennamine: drug discrimination and mu-receptor binding assay

Characterization of the interaction of pentazocine and tripelennamine: drug discrimination and mu-receptor binding assay. Shook, J. E.; Kallman, M. J.; Martin, B. R.; Dewey, W. L. (Med. Coll. Virginia, Virginia Commonw. Univ., Richmond, VA 23298, USA). Pharmacol., Biochem. Behav., 21(6), 877-81 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Abuse of the combination of pentazocine (P) [359-83-1] and tripelennamine (T) [91-81-6] reputedly produces as opiate-like euphoria not obtainable from either drug alone. To det. if this effect is related to interactions at the behavioral or receptor levels this combination was tested in rats trained to discriminate morphine from saline and in mu-receptor binding assays. Displacement of 3H-DHM was compared in morphine [57-27-2]-naive, dependent and withdrawn states to det. the importance of prior morphine exposure. The morphine training cue (3 mg/kg) generalized to P but not to T. Combinations of T (0.3 and 1.0 mg/kg) with "no effect" doses of P (1 and 3 mg/kg) resulted greater than additive increases in morphine-like responding. 3H-DHM was displaced by P but not T in naive, dependent and withdrawn states. Specific dose combinations of T (1 nM) with P (1 nM, 10 nM, 100 nM) resulted in enhanced displacement of 3H-DHM and was not related to prior morphine exposure. Thus, the addn. of T to P increases the mu-like subjective effects of P and this effect may be due to enhanced affinity of P for the mu-receptor.