Detail of "35920-39-9"

Reference

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS-A release from human lung fragments

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS-A release from human lung fragments. Hillyard, P. A.; Nials, A. T.; Skidmore, I. F.; Vardey, C. J. (Dep. Respiratory Pharmacol., Glaxo Group Res. Ltd., Ware/Hertfordshire SG12 0DJ, UK). Br. J. Pharmacol., 83(2), 337-45 (English) 1984. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 15 The inhibitory effects of a range of natural and synthetic derivs. of adenosine [58-61-7] on the antigen-induced release of histamine [51-45-6] and slow reacting substance of anaphylaxis (SRS-A) from human lung were studied. The nucleotides ATP [56-65-5], ADP [58-64-0], and AMP [61-19-8] appeared to act by being converted to adenosine. The rank order of inhibitory potency of the synthetic analogs indicated that these compds. act at an extracellular A2/Ra purinoceptor. 1,3-Diethyl-8-phenylxanthine, 8-phenylthiophylline, and theophylline antagonizied the inhibitory action of N-ethylcarboxamideadenosine [35920-39-9] competitively, but theobromine was inactive. This supported the view that the inhibitory receptor is of the A/R type. Hexobendine and dipyridamole, reported to antagonize the uptake of adenosine, failed to modify the response of human lung fragments to adenosine. The P site agonist 2',5'-dideoxyadenosine [6698-26-6] inhibited the release of histamine and SRS-A. This effect was not prevented by the inhibitors of uptake, hexobendine and dipyridamole and it was not antagonized by the nonselective A/R receptor antagonist 8-phenylthiophylline.

Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites

Antagonism of the behavioral effects of L-phenylisopropyladenosine (L-PIA) by caffeine and its metabolites. Logan, Lance; Carney, John M. (Coll. Med., Univ. Oklahoma, Oklahoma City, OK 73190, USA). Pharmacol., Biochem. Behav., 21(3), 375-9 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Three male Sprague-Dawley strain rats were trained to respond under a multi-component time out 5 min variable ratio 15 (VR15) schedule of food reinforcement. Cumulative, within session dose-effect curves were detd. for L-phenylisopropyladenosine (L-PIA) [38594-97-7] alone and after methylxanthine pretreatment. L-PIA alone produced dose related decreases on VR15 responding at doses between 0.032 and 0.178 mg/kg. Significant antagonism of L-PIA was demonstrated from pretreatment with caffeine [58-08-2], theophylline [58-55-9], theobromine [83-67-0], paraxanthine [611-59-6], 3-methylxanthine [1076-22-8], and 7-methylxanthine [552-62-5]. No antagonism of L-PIA was obsd. following pretreatment with 1-methylxanthine [6136-37-4]. Consistent with the adenosine receptor blockade hypothesis, caffeine also antagonized the effects of 5'-N-ethylcarboxamide adenosine (NECA) [35920-39-9] on VR15 responding.