Detail of "35988-42-2"

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Carboxyatractylate- and cyclosporin A- sensitive uncoupling in liver mitochondria of ground squirrels during hibernation and arousal

Carboxyatractylate- and cyclosporin A- sensitive uncoupling in liver mitochondria of ground squirrels during hibernation and arousal. Amerkhanov, Z. G.; Yegorova, M. V.; Markova, O. V.; Mokhova, E. N. ( Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Pushchino 142292, Russia). Biochemistry and Molecular Biology International, 38(5), 863-870 (English) 1996 Academic. CODEN: BMBIES. ISSN: 1039-9712. DOCUMENT TYPE: Journal CA Section: 13 (Mammalian Biochemistry) Section cross-reference(s): 1 Oxygen consumption and transmembrane elec. p. 35988-42-2 and 59865-13-3 are also in the experiment.d. in liver mitochondria from hibernating, arousing and active ground squirrels have been compared. It is found that arousal from hibernation is accompanied by uncoupling which is mediated by two different mechanisms, one sensitive to cyclosporin A and the other suppressed by carboxyatractylate. Both uncoupling effects reach their maxima at 20-25°C body temps. Involvement of an increase in the free fatty acid concn. in the arousal-induced uncoupling mechanisms is discussed. .

Zearalenone - induced uncoupling in plant mitochondria is sensitive to 6-ketocholestanol

Zearalenone - induced uncoupling in plant mitochondria is sensitive to 6-ketocholestanol. Macri, F.; Vianello, A.; Braidot, E.; Petrussa, E.; Mokhova, E.N. ( Department of Biology and Agro-industrial Economics, University of Udine, Udine I-33100, Italy). Biochemistry and Molecular Biology International, 39(5), 1001-1006 (English) 1996 Academic. CODEN: BMBIES. ISSN: 1039-9712. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In the present paper, the mechanism of zearalenone (F-2)-induced uncoupling in pea mitochondria was studied. The uncoupling by F-2 was partially reversed by 6-ketocholestanol (kCh) under conditions in which kCh completely reversed the carbonyl cyanide p-trifluoromethoxyphenylhydrazone-induced uncoupling and almost did not affect the palmitate-induced uncoupling. 35988-42-2 and 1175-06-0 which are cas registry numbers of substances are two of reagents here. Recoupling effects of carboxyatractylate, ADP and cyclosporin A were small and could not essentially decrease the kCh-insensitive part of F-2-induced uncoupling. It is suggested that a protein, mediating kCh-sensitive uncoupling, is involved in the F-2 effect in plant mitochondria. .