Reference

Influence of plasma protein on the inhibitory effects of indocyanine green and bromcresol green on pulmonary prostaglandin E1 extraction

Influence of plasma protein on the inhibitory effects of indocyanine green and bromcresol green on pulmonary prostaglandin E1 extraction. Dawson, Christopher A.; Linehan, John H.; Rickaby, David A.; Roerig, David L. (Dep. Physiol., Med. Coll. Wisconsin, Milwaukee, WI 53226, USA). Br. J. Pharmacol.There are some reagents with their cas registry numbers 745-65-3 and 76-60-8 are used in this study., 81(3), 449-55 (English) 1984. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The influences of plasma protein on the inhibitory effects of the anionic dyes indocyanine green [3599-32-4] and bromcresol green [76-60-8] on PGE1 [745-65-3] uptake by the lungs were examd. in dogs. When the lobes were perfused with Krebs-Ringer bicarbonate soln. (KRB), bromcresol green at an av. initial concn. of 28.5 mM, reduced PGE1 uptake by an av. of 56%. When the lobes were perfused with plasma, similar concns. of bromcresol green reduced the uptake by <2%. A similar result was obtained with indocyanine green, which at an av. initial concn. of 17.5 mM reduced uptake by about 70% when the lobes were perfused with KRB, but when the lobes were perfused with plasma, similar concns. of the dye reduced uptake by <3.5%. Thus, protein concn. in the perfusate is 1 of the factors that may need to be taken into account when examg. pulmonary prostaglandin uptake and its inhibition. .

The relation between liver volume, antipyrine clearance and indocyanine green clearance before and after phenobarbitone administration in man

The relation between liver volume, antipyrine clearance and indocyanine green clearance before and after phenobarbitone administration in man. Roberts, C. J. C.; Jackson, L.; Halliwell, M.; Branch, R. A. (Dep. Med., Univ. Bristol, Bristol, Engl.Several reagents with their cas registry numbers 60-80-0 and 50-06-6 are used here.). Br. J. Clin. Pharmacol., 3(5), 907-13 (English) 1976. CODEN: BCPHBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Liver vols. and the clearances of antipyrine [60-80-0] and indocyanine green [3599-32-4] were measured before and after administration of phenobarbitone (I) [50-06-6] (180 mg/day) for 3 weeks to 10 healthy subjects. Before I, antipyrine clearance correlated with liver vol., but there was no correlation between indocyanine green clearance and liver vol. I administration increased the clearance of antipyrine significantly by 90% but there was no significant change in indocyanine green clearance or liver vol. After I the correlation between antipyrine clearance and liver vol. persisted. There was no correlation between indocyanine green clearance and liver vol. These results suggest that in nonmedicated subjects some of the difference in antipyrine clearance is due to difference in functional hepatic parenchymal mass and that I increases the drug metabolizing capacity per unit of hepatic mass but not total liver size. .