Detail of "360-97-4"

CAS Number:
360-97-4
Name:
1H-Imidazole-4-carboxamide,5-amino-
Superlist Name:
5-Amino-4-imidazolecarboxamide
Molecular Structure:
Formula:
C₄H₆N₄O
Molecular Weight:
126.12
Deleted CAS:
932-15-0
Synonyms:
Imidazole-4-carboxamide,5-amino- (8CI);4-Amino-5-carbamoylimidazole;4-Aminoimidazole-5-carboxamide;4-Carbamoyl-5-aminoimidazole;4-Carboxamido-5-aminoimidazole;5-Amino-1H-imidazole-4-carboxamide;5-Amino-4-carbamoylimidazole;5-Aminoimidazole-4-carboxamide;AIC;AICA;Ba 2756;NSC 7784;
EINECS:
206-641-4
Density:
1.538 g/cm³
Melting Point:
164-170 °C(lit.)
Boiling Point:
522.1 °C at 760 mmHg
Flash Point:
269.6 °C
Solubility:
soluble in water
Appearance:
White to Off-White Solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

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5-Amino-4-imidazolecarboxyamide and D-ribose: 5-Amino-4-imidazolecarboxyamide and D-ribose. Sano, Konosuke; Yokozeki, Kenzo; Matsuda, Keizo; Mitsugi, Koji (Ajinomoto Co., Inc., Japan). Japan. Kokai JP 52012985 31 Jan 1977 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C12D013-00. APPLICATION: JP 75-789512 22 Jul 1975. DOCUMENT TYPE: Patent CA Section: 16 (Fermentations) 5-Amino-4-imidazolecarboxyamidyl riboside (I) [62981-35-5] was hydrolyzed to 5-amino-4-imidazolecarboxyamide (II) [360-97-4] and D-ribose [50-69-1] catalyzed by an enzyme produced by Achromobacter, Aeromonas, Alcaligenes, Arthrobacter, Brevibacterium, Corynebacterium, Enterobacter, Erwinia, Escherichia, Flavobacterium, Kluyvera, Microbacterium, Micrococcus, Planococcus, Proteus, Pseudomonas, Sarcina, Serratia, Sporosartina, Staphylococcus, or Vibrio. Thus, Flavobacterium ferrugineum AJ 2519 was cultured with shaking at 30.degree. for 15 h on a medium (pH 7.0) contg. yeast ext. 1, peptone 1, NaCl 0.5, and I 0.4%. To 100 mL culture broth, 100 mL of 20% I was added and incubated at 55.degree. and pH 7.0 for 18 h. Prodn. of II and D-ribose was 4.75 and 4.65 g/dL, resp.

Aryl and heterocyclic diazo compounds as potential environmental electrophiles: Aryl and heterocyclic diazo compounds as potential environmental electrophiles. Lower, Gerald M., Jr.; Lanphear, Steven P.; Johnson, Bruce M.; Bryan, George T. (Cent. Health Sci., Univ. Wisconsin, Madison, Wis., USA). J. Toxicol. Environ. Health, 2(5), 1095-107 (English) 1977. CODEN: JTEHD6. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) 4-Aminoimidazole-5-carboxamide [360-97-4], a component of human urine derived from the de novo purine biosynthetic pathway, was evidenced to undergo in vivo diazotization in rats following its sequential administration with NaNO2. The diazotization product, 4-diazoimidazole-5-carboxamide (I) [24316-91-4], undergoes intramolecular cyclization to yield 2-azahypoxanthine (II) [4656-86-4], the urinary presence of which was confirmed mass spectrometrically. I demonstrated dose-related mutagenicity in Salmonella typhimurium TA 100 and represents a potent electrophilic reactant similar to the proposed ultimate carcinogenic forms of arylalkylnitrosamines and arylnitrosamides.