Detail of "36085-73-1"

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Cardiovascular effects in rats of alpha1 and alpha2 adrenergic agents injected into the nucleus tractus solitarii

Cardiovascular effects in rats of alpha1 and alpha2 adrenergic agents injected into the nucleus tractus solitarii. Kubo, T.; Kihara, M.; Hata, H.; Misu, Y. (Sch. Med., Yokohama City Univ., Yokohama 232, Japan). Naunyn-Schmiedeberg's Arch. Pharmacol., 335(3), 274-7 (English) 1987. CODEN: NSAPCC. ISSN: 0028-1298. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The cardiovascular effects of selective a1 and a2 agonists and antagonists injected into the nucleus tractus solitarii (NTS) were studied in urethane-anesthetized rats. Methoxamine [390-28-3] (0.3-3 mg) injected bilaterally into the NTS caused a dose-dependent increase in blood pressure and heart rate.Several substances with their cas registry numbers 15327-38-5 and 6539-57-7 may be metioned in this study. Phenylephrine [59-42-7] (6 mg) and an imidazolidine deriv. St 587 [15327-38-5] (3 mg) similarly injected also produced an increase in blood pressure, whereas a-methylnoradrenaline [6539-57-7] and an azepine deriv. B-HT 920 [36085-73-1] (1 and 3 mg) caused a decrease in blood pressure and heart rate. The pressor response to methoxamine (1 mg) was markedly inhibited by prazosin (0.3 mg) injected into the same sites or hexamethionum (25 mg/kg, i.v.). Prazosin (0.3 mg) alone injected bilaterally into the NTS did not affect the blood pressure, whereas yohimbine (0.1 mg) similarly injected increased the pressure. In the rat NTS, there apparently exist a1-adrenoceptors responsible for an increase in arterial pressure. The NTS a1-adrenoceptors seem to be involved in the tonic regulation of arterial pressure. .

Lisuride-induced mounting and its modification by drugs active on adrenergic and dopaminergic receptors

Lisuride-induced mounting and its modification by drugs active on adrenergic and dopaminergic receptors. Ferrari, F.; Baggio, G.; Mangiafico, V. (Inst. Pharmacol., Univ. Modena, Modena I-41100, Italy). Pharmacol. Res. Commun., 18(12), 1159-68 (English) 1986. CODEN: PLRCAT. ISSN: 0031-6989. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Imidazole (IMID) [288-32-4] (9.37-75 mg/kg) and yohimbine (YOH) [146-48-5], (0.5-2.5 mg/kg), strongly potentiated lisuride hydrogen maleate [19875-60-6]-induced mounting; whereas, clonidine [4205-90-7] (150 mg/kg) antagonized the phenomenon. A high (2 mg/kg) but not a low (50 mg/kg) dose of B-HT 920 [36085-73-1] and (3,4-dihydroxyphenylamino)-2-imidazoline (DPI) [57101-49-2] (100 and 500 mg/kg) also inhibited lisuride-induce mounting. While, at present, the IMID-specific activity in the monaminergic system is not yet conclusively known, it is demonstrated that, at the doses used, YOH and clonidine are selective a2 antagonist and agonist, resp.; B-HT 920 preferentially stimulates D2 receptors at 50 mg/kg and a2 receptors at 2mg/kg; DPI, proposed as a DAI agonist, also activates a2 receptors. Therefore, in view of the dose-related receptorial selectivity of action of the drugs tested, neurochem. 4205-90-7 and 19875-60-6 are just another two chemicals used in this study. mechanisms on specific receptors involved for modulation of this form of sexual behavior are briefly discussed. .