Reference

Antiallergic properties of dimebone, phencarol and ketotifen during sensitization with ragweed pollen

Antiallergic properties of dimebone, phencarol and ketotifen during sensitization with ragweed pollen. Galenko-Yaroshevskii, P. A.; Shadurskii, K. S.; Il'yuchenok, T. I.; Pasechnikov, F. G.; Khanferyan, R. A.; Sergan, V. Ya.; Sazonov, S. R. (Kuban. Med. Inst., Krasnodar, USSR). Farmakol. Toksikol. (Moscow), 47(3), 75-8 (Russian) 1984. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In guinea pigs sensitized with ragweed (Ambrosia artemisiifolia) pollen dimebone [3613-73-8] (an antihistaminic drug) exerts a marked antianaphylactic effect which compares very favorably with that of phencarol [10447-38-8]. When administered in the minimal EDs, dimebone is less active than ketotifen [34580-13-7], whereas in doses of 2.5 and 5 mg/kg it is more effective. The marked anaphylactic activity of the drug is accounted for by its antihistaminic and antiserotonin actions. When administered intragastrically, s.c., and i.v., dimebone is less toxic than phencarol (1.28-, 1.78-, and 1.43-fold, resp.) and ketotifen (1.78-, 1.68-, and 5-fold, resp.).

Study of some pharmacological properties of dimebone on healthy and irradiated animals

Study of some pharmacological properties of dimebone on healthy and irradiated animals. Matveeva, I. A.; Il'yuchenok, T. Yu.; Yurovskaya, M. A. (USSR). Deposited Doc., VINITI 5026-83, 13 pp. Avail. VINITI (Russian) 1983. DOCUMENT TYPE: Report CA Section: 1 (Pharmacology) The toxicol. and pharmacol. actions of dimebone [3613-73-8] in normal lab. animals and animals with radiation sickness are summarized. Dimebone is an antihistaminic, antianaphylactic, and anti-inflammatory agent.