Reference

Preparation of 2-hydroxybenzamidines from 3-aminobenzisoxazoles

Preparation of 2-hydroxybenzamidines from 3-aminobenzisoxazoles.Several substances are used for example 36216-80-5 which is its cas registry number. Lepore, Salvatore D.; Schacht, Aaron L.; Wiley, Michael R. (Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA). Tetrahedron Letters, 43(48), 8777-8779 (English) 2002 Elsevier Science Ltd. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) 2-Hydroxybenzamidines have been prepd. from 3-aminobenzisoxazoles by reductive cleavage of the nitrogen-oxygen bond using catalytic hydrogenation, Zn/AcOH or NiCl2/NaBH4. This ring-opening reaction can be accomplished chemoselectively in the presence of a variety of hydrogenation-sensitive functional groups including an aryl bromide, benzyl carbamate, and olefin. .