Detail of "3625-06-7"

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Stability study and quantitative determination of mebeverine hydrochloride in tablets by means of reversed-phase high-performance liquid chromatography

Stability study and quantitative determination of mebeverine hydrochloride in tablets by means of reversed-phase high-performance liquid chromatography. De Schutter, J. A.; De Croo, F.; Van der Weken, G.; Van den Bossche, W.; De Moerloose, P. (Dep. Pharm. Chem. Drug Qual. Control, State Univ. Gent, Ghent B-9000, Belg.). Chromatographia, 20(3), 185-92 (English) 1985. CODEN: CHRGB7. ISSN: 0009-5893. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Mebeverine (I) [3625-06-7], as I-HCl [2753-45-9], was detd. in tablets by reversed-phase HPLC. Elution was performed on an octyl silane column with MeOH-H2O (75-25), contg. 0.05% hexylamine as silanol-blocking agent, adjusted to pH 5.0 with H3PO4. The method gave accurate, precise and reproducible results. The mean recovery of the drug from 6 synthetic tablets mixts. was 100.0% with a relative std. deviation of 0.94%. The interference of the degrdn. compds. of I-HCl and of the intermediates from the synthesis was investigated. None of them interfered. The degrdn. compds. of I were identified as veratric acid [93-07-2] and 4-[ethyl-[2-(4-methoxyphenyl)-1-methylethyl]amino]-1-butanol [14367-47-6], by mass spectrometry and UV-spectrophotometry. I-HCl is very stable in tablets; the tablets still contain >95% of the declared drug potency after storage more than one year at 50°.

Effects of spasmolytics on potassium-induced contraction of rat intestine in vivo

Effects of spasmolytics on potassium-induced contraction of rat intestine in vivo. Subissi, Alessandro; Brunori, Paola; Bachi, Moreno (Dep. Pharmacol., Lab. Guidotti S.p.A., Pisa 56010, Italy). Eur. J. Pharmacol., 96(3-4), 295-301 (English) 1983. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Eight spasmolytic drugs commonly used in the treatment of the irritable bowel syndrome were compared to verapamil [52-53-9] with respect to their effects (all drugs injected i.v.) on the contraction of duodenum, ileum, and colon induced by high-K+ topical application in the anesthetized rat. Verapamil > rociverine citrate [89026-32-4] > papaverine [58-74-2] > mebeverine [3625-06-7] > dicyclomine [77-19-0] antagonized dose-dependently the contraction of duodenum and colon, the activity on duodenum being from 2- (rociverine) to 10-fold (verapamil) higher. Verapamil and rociverine, but not the other drugs, were also active on ileum. N-Butylscopolammonium bromide [149-64-4], phloroglucinol [108-73-6] and trimebutine maleate [34140-59-5] were inactive against the contraction of the 3 intestinal regions, and prifinium bromide [4630-95-9] was inactive on duodenum and ileum, while having remarkable activity on colon (unrelated to its antimuscarinic activity). The results are discussed briefly with ref. to the pharmacol. therapy of the irritable bowel syndrome.