Reference

Photosensitizing properties of nonsteroidal antirheumatic agents determined by the photopatch test

Photosensitizing properties of nonsteroidal antirheumatic agents determined by the photopatch test. Przybilla, Bernhard; Ring, Johannes; Schwab, Ulrike; Galosi, Attila; Dorn, Michael; Braun-Falco, Otto (Dermatol. Klin. Poliklin., Ludwig-Maxmilians-Univ, Munich D-8000/2, Fed. Rep. Ger.). Hautarzt, 38(1), 18-25 (German) 1987. CODEN: HAUTAW. ISSN: 0017-8470. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In photopatch tests for skin photosensitization to UV-A plus UV-B light by 6 nonsteroidal antirheumatic drugs, the following percentages of the subjects gave a pos. reaction: aspirin [50-78-2] 9. 50-78-2 and 15307-86-5 which are cas registry numbers are also used here.2, carprofen [53716-49-7] 24.4, diclofenac [15307-86-5] 6.7, ketoprofen [22071-15-4] 3.8, piroxicam [36322-90-4] 8.3, and tiaprofenic acid [33005-95-7] 24.6%. Most of the pos. reactions could be elicited by UV-A light alone; in some cases UV-A plus UV-B was necessary; only rarely did pos. reactions occur with UV-B alone. The high incidence of pos. reactions is a possible indication of phototoxic action of these drugs; however, in some cases a photoallergic mechanism seems likely. .

Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil

Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil. Nigro, Norman D.; Bull, Arthur W.; Boyd, Miriam E. (Sch. Med., Wayne State Univ., Detroit, MI 48226, USA). JNCI, J. Natl. Cancer Inst., 77(6), 1309-13 (English) 1986. CODEN: JJIND8. ISSN: 0198-0157. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) An inhibitor of ornithine decarboxylase [9024-60-6], difluoromethylornithine (DFMO) [70052-12-9], and 2 inhibitors of prostaglandin biosynthesis, piroxicam (I) [36322-90-4] and menhaden fish oil, were examd. for their effect on intestinal tumorigenesis in rats fed a 5% fat semisynthetic diet. Each agent was given individually in one of two doses as follows: DFMO, 0.05 or 0.1% in the drinking water; piroxicam, 65 or 130 mg/kg diet; and menhaden fish oil, 1.25 or 2.Several substances with their cas registry numbers 9024-60-6 and 70052-12-9 may be metioned in this study.50% of the diet. Addnl. animal groups were given combinations of the lower dose of DFMO and the lower dose of either piroxicam or fish oil. Intestinal tumors were induced by s.c. injections of azoxymethane (AOM) [25843-45-2] at 8 mg/kg weekly for 8 wk. Test diets were started 1 wk prior to the 1st dose of AOM, and the rats were sacrificed 26 wk later. Rats that received either dose of DFMO or the high dose of I developed fewer intestinal tumors compared to controls. The low dose of I and the fish oil given at either dose level had no effect. The combination of the low dose of DFMO and the low dose of I reduced tumor formation more than either dose of DFMO alone, whereas the low dose of DFMO and fish oil together was no more effective than either dose of DFMO alone. Apparently, a combination of a small amt. of DFMO and I, each acting through a different mechanism, exerts an additive inhibitory effect on intestinal tumor formation in rats. .