CAS No.36330-85-5,Fenbufen Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	36330-85-5
Name:	Fenbufen
Article Data:	54

Formula:	C₁₆H₁₄O₃
Molecular Weight:	254.285
Synonyms:	Propionicacid, 3-(4-biphenylylcarbonyl)- (6CI);3-(4-Biphenylcarbonyl)propionic acid;3-(4-Phenylbenzoyl)propionic acid;3-[(Biphenyl-4-yl)carbonyl]propionic acid;4-(4-Phenylphenyl)-4-oxobutyric acid;4-(Biphenyl-4-yl)-4-oxobutanoic acid;Bufemid;CL 82204;Cinopal;Cinopol;Lederfen;Napanol;g-Oxo[1,1'-biphenyl]-4-butanoicacid;[1,1'-Biphenyl]-4-butanoicacid, g-oxo-;
EINECS:	252-979-0
Density:	1.188 g/cm³
Melting Point:	184-187 °C(lit.)
Boiling Point:	470.2 °C at 760 mmHg
Flash Point:	252.3 °C
Solubility:	2.212mg/L(25 oC)
Appearance:	White solid
Hazard Symbols:	T
Risk Codes:	25
Safety:	28-45
Transport Information:	UN 2811 6.1/PG 3
PSA:	54.37000
LogP:	3.40110

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Chemistry

Molecular Formula: C₁₆H₁₄O₃
Molecular Weight: 254.28
EINECS: 252-979-0
Density: 1.188 g/cm³
Flash Point: 252.3 °C
Appearance: White Solid
Index of Refraction: 1.585
CAS Registry Number: 36330-85-5
Melting Point: 184-187 °C(lit.)
Enthalpy of Vaporization: 77.19 kJ/mol
Boiling Point: 470.2 °C at 760 mmHg
Vapour Pressure: 1.21E-09 mmHg at 25 °C
IUPAC Name: 4-Oxo-4-(4-phenylphenyl)butanoic acid
Synonyms: Fenbufen ; Gamma-oxo-[1,1'-biphenyl]-4-butanoic acid ; 4-(4-Biphenyl)-4-oxobutyric acid ; 3-(4-phenylbenzoyl)propionic acid ; 1’-(biphenyl)-4-butanoicacid,gamma-oxo- ; 3-(4-Biphenylylcarbonyl)-propionicacid
Following is the molecular structure of 3-(4-Biphenylylcarbonyl)-propionic acid (CAS NO.36330-85-5):

Uses

3-(4-Biphenylylcarbonyl)-propionic acid (CAS NO.36330-85-5) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. 3-(4-Biphenylylcarbonyl)-propionic acid is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. 3-(4-Biphenylylcarbonyl)-propionic acid (CAS NO.36330-85-5) acts by preventing cyclooxygenase from producing the prostaglandins that cause inflammation.

Production

Producte method: In the presence of anhydrous aluminum chloride, biphenyl, and succinic anhydride in nitrobenzene in the condensation, the system was fenbufen, the yield was 70%.

Toxicity Data With Reference

1.	orl-wmn TDLo:12 mg/kg/1D-I	BMJOAE British Medical Journal. 290 (1985),822.
2.	orl-man TDLo:90 mg/kg/1W-I:PUL	HUTODJ Human Toxicology. 7 (1988),35.
3.	orl-rat LD50:200 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 30 (1980),725.
4.	ipr-rat LD50:265 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 30 (1980),721.
5.	scu-rat LD50:247 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 30 (1980),721.
6.	orl-mus LD50:795 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 30 (1980),721.
7.	ipr-mus LD50:482 mg/kg	PCIPDV Beijing Yixueyuan Xuebao. Journal of Peking Medical College. 15 (1983),132.
8.	scu-mus LD50:1189 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 10 (1979),884.

Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: cough, sweating, body temperature. An experimental teratogen. Other experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of 3-(4-Biphenylylcarbonyl)-propionic acid (CAS NO.36330-85-5):
Hazard Codes: T Toxic
Risk Statements: 25
R25: Toxic if swallowed.
Safety Statements: 28-45
S28: After contact with skin, wash immediately with plenty of soap-suds.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DV1761000
HazardClass: 6.1
PackingGroup: III