Detail of "3635-74-3"

Reference

Composition for stimulating the central nervous system

Composition for stimulating the central nervous system. Cojocaru, Zenaida; Oita, Nicolae; Rusu, Georgeta; Sauciuc, Tatiana; Mungiu, Costel; Neacsu, Ion (Intreprinderea de Medicamente, Bucuresti, Rom.). Rom. RO 83820 B 30 Apr 1984, 2 pp. (Romanian). (Romania). CODEN: RUXXA3. CLASS: IC: A61K009-20; A61K031-245; A61K031-44. APPLICATION: RO 82-107021 25 Mar 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Pharmaceutical compns. (capsule or tablet or hydroglycerin soln.) for stimulating the central nervous system in children and adults comprise 2-(dimethylamino)ethanol p-(acetylamino)benzoate salt (I) [3635-74-3] 15-50, 2-(diethylamino)ethanol p-(acetylamino)benzoate salt (II) [96847-83-5] 15-50, pyridoxine salt 15-50, and Al nicotinate [1976-28-9] 5-15 g. Thus, for 1000 capsules or tablets a formulation contained 15 g each I and II, 50 g of each pyridoxine glycerophosphate salt [96928-48-2] and pyridoxine acetylglutamate salt [17091-87-1], lactose 300, and Mg stearate 30 g.

Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation

Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. Zahniser, Nancy R.; Chou, David; Hanin, Israel (Sch. Pharm., Univ. Pittsburgh, Pittsburgh, Pa., USA). J. Pharmacol. Exp. Ther., 200(3), 545-59 (English) 1977. CODEN: JPETAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A specific and sensitive gas chromatog. assay to measure deanol [108-01-0] levels in tissue was developed and applied to studies of the effect of acute Deaner (deanol p-acetamidobenzoate) [3635-74-3] administration on deanol, acetylcholine [51-84-3] and choline [62-49-7] levels in rodent brains. This procedure is quantitative and yields reproducible results over a wide range of deanol concns. (0.30-200 nmol). In control rodent brain, liver, heart, lung and plasma, no free endogenous deanol (>1 nmol/g) was detected. After deanol administration, deanol was detected in tissues. Regardless of deanol pretreatment time (1-30 min) or doses (33.3-3000 mg/kg i.p.) used, no increase in mouse whole brain acetylcholine levels was detected. Likewise, there was no detectable elevation in acetylcholine levels in rat whole brain, cortex, striatum or hippocampus after a 15-min pretreatment with 550 mg/kg of deanol (i.p.).There are some commonly used reagents with their cas registry numbers 3635-74-3 and 62-49-7 in this article. The only elevation in acetylcholine levels which were detected occurred selectively in the striatum of mice pretreated with a massive dose (900 mg/kg i.p.) of deanol for 30 min. This selective increase in striatal acetylcholine levels could not, however, be related to levels of deanol in the striatum because there was no greater accumulation of deanol in the striatum than in other brain areas tested or in whole brain. These data do not confirm the results of other investigators who reported elevations in whole brain or striatal acetylcholine levels after acute administration of lower doses of deanol. The data emphasize the need for further investigation into the mode of action of deanol and question its suggested role as an immediate precursor of acetylcholine synthesis in the central nervous system. .