Detail of "364-98-7"

Reference

Effects of diazoxide on maternal and fetal circulations in normotensive and hypertensive pregnant sheep

Effects of diazoxide on maternal and fetal circulations in normotensive and hypertensive pregnant sheep. Wallenburg, H. C. S.; Kuijken, J. P. J. A. (Med. Sch., Erasmus Univ., Rotterdam, Neth.). J. Perinat. Med., 12(2), 85-95 (English) 1984. CODEN: JPEMAO. ISSN: 0300-5577. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Administration of diazoxide [364-98-7] to hypertensive and normotensive pregnant sheep resulted in a marked drop in maternal arterial pressure, a rise in heart rate, and a fall in uterine and renal blood with a rise in vascular resistance; simultaneously, there was a transient fall in fetal heart rate with a drop in pO2 and pH. When diazoxide was administered in combination with a plasma expander, maternal blood pressure fell only in the hypertensive group with no decrease in uterine and renal blood flow; fetal variables remained unchanged. Thus, the undesirable fall in uteroplacental blood flow obsd. after diazoxide may be avoided with the use of a plasma expander preventing adverse effects on the fetus in preeclamptic patients.

A comparative study on possible calcium antagonistic properties of indapamide and other drugs potentially interfering with calcium transport in isolated vascular smooth muscle

A comparative study on possible calcium antagonistic properties of indapamide and other drugs potentially interfering with calcium transport in isolated vascular smooth muscle. De Wildt, Dick J.; Hillen, Feddo C. (Lab. Pharmacol., Natl. Inst. Public Health Environ. Hyg., Bilthoven 3720 BA, Neth.). Eur. J. Pharmacol., 102(3-4), 401-10 (English) 1984. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In the present study the effects of indapamide (IN)(I) [26807-65-8] were compared with those of chlorthalidone (C) [77-36-1] and of drugs potentially interfering with calcium transport, e.g. verapamil (V) [52-53-9], papaverine (P) [58-74-2], phentolamine (PH) [50-60-2] and diazoxide (D) [364-98-7] using isolated rabbit aorta in order to detect calcium antagonistic properties. IN and C failed to show any relaxation effect towards either noradrenaline (NA)- or high K+-precontracted aorta strips, whereas V and P reduced the K+ contraction dose dependently and PH, V, P and D induced a significant relaxation of the NA contraction. Preincubation with IN or C did not affect the dose-response curve of NA-induced contractions. PH antagonized the NA contraction strongly whereas V and P shifted the dose-response curve to the right only at the highest concn. In a Ca2+-depleted and high K+-depolarized aorta preincubation with V was able to antagonize Ca2+-induced contraction effectively in a dose-dependent fashion whereas P only showed partial inhibition at the highest concn. The effects of the drugs on responses to NA in a Ca2+-free medium were also investigated. This type of contraction is likely to be due to mobilization of internally located Ca2+. The results demonstrate that PH was able to counteract this type of contraction effectively whereas only a high concn. of V, P and D was effective in reducing the Na contraction in Ca2+-free medium. Both IN and C failed to affect this type of contraction. In conclusion, the present results indicate that neither IN nor C possess calcium entry and or intracellular calcium antagonistic properties under different conditions as measured in a conduit vessel of rabbits. Moreover, the results point to an addnl. site of calcium antagonistic action for V, P and D, esp. at higher concns.