Reference

Immunopharmacological studies on Mydocalm and related compounds as an antagonist of slow reacting substance of anaphylaxis (SRS-A)

Immunopharmacological studies on Mydocalm and related compounds as an antagonist of slow reacting substance of anaphylaxis (SRS-A). Nagai, Hiroichi; Matsuura, Naosuke; Sato, Natsuki; Koda, Akihide; Kohno, Shigekatsu (Dep. Pharmacol., Gifu Coll. Pharm., Gifu 502, Japan). J.Some commonly used reagents like 3644-61-9 is used in this experiment. Pharmacobio-Dyn., 6(11), 874-80 (English) 1983. CODEN: JOPHDQ. ISSN: 0386-846X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The antagonistic effect of Mydocalm (I) [3644-61-9] and its 15 derivs. against slow reacting substance of anaphylaxis (SRS-A) were examd. in vitro. Mydocalm, 2-methyl-3-piperidino-b-propionaphtone (As-5) [72637-30-0] and 2,3',4'-trimethyl-3 piperidinopropiophenone (As-14) [4067-44-1] were potent antagonists to SRS-A. The above 3 compds. inhibited homologous passive cutaneous anaphylaxis (PCA) in rats and guinea pigs but not heterologous PCA in guinea pigs. As-5 inhibited the release of histamine [51-45-6] from and the degranulation of rat mesenterium mast cells. As-14 also inhibited degranulation. Mydocalm, however, did not inhibit these reactions. Exptl. asthma in guinea pigs which were passively sensitized with guinea pig IgE antibody was significantly inhibited by oral administration of Mydocalm, As-5 or As-14 resp. .

Voltammetric electrodes for dissolution rate studies

Voltammetric electrodes for dissolution rate studies. Kolbe, I.; Feher, Z. (Gedeon Richter Ltd., Budapest, Hung.). Anal. Chem. Symp. Ser., 18(Mod. Trends Anal. Chem., Pt. A), 341-52 (English) 1984. CODEN: ACSSDR. ISSN: 0167-6350. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 Voltammetric sensors with graphite and membrane-coated Hg electrodes were used for detg. the dissoln. rate of tablets. N-Acetyl-p-aminophenol [103-90-2] was used as the model drug. The drug gives a well-defined reproducible oxidn. peak in artificial gastric juice at pH 1.3. The half peak potential of it is +0.7V vs. Ag/AgCl ref. electrode. For flow-through measurements, the 0.85 V const. potential was suitable. Excipients do not interfere in the voltammetric behavior of the compd. A linear relation was obsd. between the voltammetric current and concn. of the drug. The results of a dissoln. test of coated tablets contg. a reducible drug, tolperisone-HCl [3644-61-9], are discussed. A well-defined, reproducible voltammetric peak was obsd. by using a membrane-coated static Hg electrode. The peak current vs. concn. plot is linear. The std. deviation is 1.4%.