Detail of "36441-41-5"

Reference

Amikacin, an aminoglycoside with marked activity against antibiotic-resistant clinical isolates

Amikacin, an aminoglycoside with marked activity against antibiotic-resistant clinical isolates. Price, K. E.; DeFuria, M. D.; Pursiano, T. A. (Bristol Lab., Div., Bristol-Myers Co.Chemicals with cas numbers 37517-28-5 and 34493-98-6 also play role., Syracuse, N. Y., USA). J. Infect. Dis., 134(Suppl.), S249-S261 (English) 1976. CODEN: JIDIAQ. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) A total of 319 clin. isolates known to be resistant to .gtoreq.1 aminoglycoside antibiotic were tested for their susceptibility to 10 aminoglycosides. The susceptibility percentages of isolates found by an agar diln. method were: amikacin (I) [37517-28-5], 83.7%; tobramycin [32986-56-4], 41.4%; butirosin A [34291-02-6], 33.2%; dideoxykanamycin B [34493-98-6], 32.6%; gentamicin C [11097-82-8], 27.3%; lividomycin A [36441-41-5], 17.6%; neomycin B [119-04-0], 10.7%; paromomycin [7542-37-2], 10.3%; kanamycin A [59-01-8], 10.0%; and ribostamycin [25546-65-0], 7.2%. The effectiveness of the antibiotics was related to their degree of resistance to bacterial enzymes; e.g., of the 9 enzymes known to inactivate antibiotics contg. 2-deoxystreptamine, I was affected by 1 enzyme, tobramycin by 5, and gentamicin and kanamycin by 6. Examn. of cell-free exts. from the 52 strains resistant to I revealed that only 4 contained the I-inactivating enzyme aminoglycoside-6'-acetyltransferase [56467-65-3]. Most I-resistant strains, which were almost invariably resistant to all aminoglycosides, lacked the ability to accumulate effectively either I or presumably the other antibiotics intracellularly. .

Aminoglycoside sensitivity of ribosomes from the archaebacterium Methanococcus vannielii: structure-activity relationship

Aminoglycoside sensitivity of ribosomes from the archaebacterium Methanococcus vannielii: structure-activity relationship. Boeck, A.; Baer, U.; Schmid, G.; Hummel, H. (Univ. Muenchen, Munich D-8000, Fed. Rep. Ger.).Several reagents with their cas registry numbers 52093-21-7 and 36441-41-5 are used here. FEMS Microbiol. Lett., 20(3), 435-8 (English) 1983. CODEN: FMLED7. ISSN: 0378-1097. DOCUMENT TYPE: Journal CA Section: 10 (Microbial Biochemistry) The effect of about 20 aminoglycoside antibiotics, comprising compds. with specific 70 S or with 70 S plus 80 S activity, on polypeptide synthesis and translational misreading by ribosomes from the archaebacterium M. vannielii was investigated. A clear structure-activity relation was found: sensitivity was obsd. only in the class of 4,5-disubstituted deoxystreptamine compds., with neomycin and paromomycin as the most active ones. The streptomycin-class aminoglycosides were completely inactive, whereas the gentamicin group solely affected misreading and only at high concns. Viomycin, a specific inhibitor of the translocation reaction at the eubacterial ribosome which competes with binding of 2-deoxystreptamine aminoglycosides, was inactive as well. .