Detail of "3646-73-9"

Reference

Synthesis of 2-imino-2-methoxyethyl-1-thio-galactose and application for liver targeting

Synthesis of 2-imino-2-methoxyethyl-1-thio-galactose and application for liver targeting. Xu, Xi-ming; Yu, Jiang-nan; Fu, Zhi-jun; Fu, Hai-zhen; Li, Qing; You, Qi-dong; Zhang, Jun-shou (School of Pharmacy, Jiangsu University, Zhenjiang 212001, Peop. Rep. China). Zhongguo Xinyao Zazhi, 13(3), 243-245 (Chinese) 2004 Zhongguo Xinyao Zazhishe. CODEN: ZXZHA6. ISSN: 1003-3734. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 33 This study was to synthesize 2-imino-2-methoxyethyl-1-thio-galactose and to observe its effect on liver targeting. 2-Imino-2-methoxyethyl-1-thio-galactose was synthesized from galactose by a series reaction including acetylation, bromization, condensation, substitution and addn. with methanol. After i.v. injection to mice, the concn. of drug in mice plasma and liver was detd. by HPLC. The product was identified by IR, MS techniques. Targeting efficiency for liver increased about 1.5 fold, after 2-imino-2-methoxyethyl-1-thio-galactose reacted successfully on the surface of albumin microspheres. Galactosyl albumin microspheres showed remarkable targeting for liver.Except for chemicals metioned above, 124-41-4 and 3646-73-9 are also used. .

Lectin/glycan interactions play a role in recognition in a coral/dinoflagellate symbiosis

All Rights Reserved. Lectin/glycan interactions play a role in recognition in a coral/dinoflagellate symbiosis. Wood-Charlson, Elisha M.; Hollingsworth, Lea L.; Krupp, Dave A.Chemicals with cas numbers 3646-73-9 and 492-62-6 also play role.; Weis, Virginia M. (Department of Zoology, Oregon State University, Corvallis, OR 97331, USA). Cellular Microbiology, 8(12), 1985-1993 (English) 2006 Blackwell Publishing Ltd. CODEN: CEMIF5. ISSN: 1462-5814. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Section cross-reference(s): 12 Recognition is an important stage in the establishment of highly specific mutualistic assocns. Yet, for the majority of symbioses, very few of the mechanisms involved in recognition and specificity are known. In this study, the authors provide evidence for a recognition mechanism at the onset of symbiosis between larvae of the coral Fungia scutaria and their endosymbiotic dinoflagellate algae. This recognition step occurs during initial cellular contact between the symbiotic partners through a lectin/glycan interaction. The authors detd. that an intact algal cell surface was required for successful infection of F. scutaria larvae. Modification of the algal cell surface by enzymic digestion with trypsin or N-glycosidase significantly reduced infection success, and implicated algal cell surface glycans in recognition. Using flow cytometry, a-mannose/a-glucose and a-galactose residues were identified as potential recognition ligands on the algal cell surface. Finally, inhibition of these cell surface glycans significantly reduced infection of F. scutaria larvae by the algae. These data provide evidence that the algal cell surface contains glycan ligands, such as a-mannose/a-glucose and a-galactose, which play a role in recognition during initial contact at the onset of symbiosis with F. scutaria larvae. .