Detail of "364782-34-3"

CAS Number:
364782-34-3
Name:
1-Naphthalenemethanamine,a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-,hydrochloride (1:1), (aR)-
Superlist Name:
Cinacalcet hydrochloride
Molecular Structure:
Formula:
C₂₂H₂₂F₃N_.HCl
Molecular Weight:
393.88
Synonyms:
Mimpara;Regpara;Sensipar;1-Naphthalenemethanamine,a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-,hydrochloride, (aR)-(9CI);
Melting Point:
175-177 °C
Boiling Point:
440.9 °C at 760 mmHg
Flash Point:
220.5 °C
Appearance:
Off-white to tan solid

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Reference

Clinical experience with cinacalcet HCl: Clinical experience with cinacalcet HCl. Torres, Pablo Urena (Clinique de l'Orangerie, Aubervilliers, Fr.).In this study， 364782-34-3 and 7723-14-0 are also used. Nephrology, Dialysis, Transplantation, 19(Suppl. 5), v27-v33 (English) 2004 Oxford University Press. CODEN: NDTREA. ISSN: 0931-0509. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. Secondary hyperparathyroidism (SHPT) is assocd. with parathyroid gland hyperplasia, increased parathyroid hormone (PTH) prodn. and secretion, disturbed bone and mineral metab., soft tissue calcification and an increased risk of death. The condition is an almost universal complication of end-stage renal disease (ESRD) and currently is managed by treatment with phosphate binders and vitamin D compds., both of which are assocd. with significant side effects, including hypercalcemia and hyperphosphatemia. Therapy with calcimimetics is a new approach to the treatment of SHPT. These agents act at the calcium-sensing receptor (CaR), where they increase the sensitivity of the receptor to ionized serum calcium. Activation of the CaR results in a rapid redn. in PTH secretion. The calcimimetic drug cinacalcet HCl currently is undergoing clin. trials in dialysis patients who have uncontrolled SHPT, despite treatment with vitamin D compds. and/or phosphate binders. Clin. trials have confirmed that the drug rapidly reduces plasma PTH, phosphorus and calcium-phosphorus product (Ca ′ P) levels, and that levels of PTH, phosphorus and Ca ′ P remain suppressed for up to 3 yr. In clin. trials, cinacalcet HCl was a well-tolerated drug; only nausea and vomiting occurred more frequently in patients who took cinacalcet HCl than in those who took placebo, and the occurrence of transient hypocalcemia was limited to the initial phase of the treatment. Cinacalcet HCl is therefore a potentially highly effective and well-tolerated treatment for SHPT in patients with ESRD. .

Calcimimetic drug: recent evidences and perspectives: All Rights Reserved. Calcimimetic drug: recent evidences and perspectives. Nagano, Nobuo (Kirin Brewery Co., Ltd. 6-26-1 Jinguumae, Shibuya-ku, Tokyo 150-8011, Japan). Jin to Toseki, 60(5), 770-776 (Japanese) 2006 Tokyo Igakusha. CODEN: JTIOAA. ISSN: 0385-2156. 364782-34-3 and 7440-70-2 which are cas registry numbers of chemicals are mentioned. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review, discussing action mechanism and clin. pharmacol. of calcimimetic drugs, including cinacalcet HCl, with regards to recent evidences and perspectives for parathyroid hyperfunction and hypercalcemia. .

Detail of "364782-34-3"

1-Naphthalenemethanamine,a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-,hydrochloride (1:1), (aR)-

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CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

CAS No.364782-34-3 Cinacalcet hydrochloride

Reference