Reference

2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methemoglobin and urine analyses

2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methemoglobin and urine analyses. Eadsforth, C. V.; Logan, C. J.; Morrison, B. J.; Warburton, P. A. (Sittingbourne Res. Cent., Shell Res. Ltd., Sittingbourne/Kent, UK). Int. Arch. Occup. 367-25-9 is just another one chemical used in this study. Environ. Health, 54(3), 223-32 (English) 1984. CODEN: IAEHDW. ISSN: 0340-0131. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Two possible methods for monitoring exposure to 2,4-difluoroaniline (I) [367-25-9] and 4-fluoroaniline [371-40-4] were investigated: measurement of metHb content in blood and measurement of urinary metabolites. Expts. using rats dosed by the oral route as a model system show that measurement of metHb content provides a very rapid and simple monitoring method, but is not very sensitive. Measurement of the O-hydroxy metabolites of the 2 compds., as their benzoxazole derivs., provides a much more sensitive, but complicated technique. Details of both methods are presented. .

2,4-Difluoro[4-(trans-4-alkylcyclohexyl)cyclohexen-1-yl]benzene

2,4-Difluoro[4-(trans-4-alkylcyclohexyl)cyclohexen-1-yl]benzene. (Chisso Corp., Japan). Jpn. Kokai Tokkyo Koho JP 58198428 A2 18 Nov 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07C025-18; C09K003-34; G09F009-35. APPLICATION: JP 82-81190 14 May 1982. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Section cross-reference(s): 75 Title compd. (I), useful as liq. crystals with low viscosity, was prepd. by reaction of 2,4-F2C6H3MgBr (II) with III followed by dehydration of the resulting IV. Thus, diazotization of 2,4-F2C6H3NH2 and subsequent treatment with CuBr afforded 2,4-F2C6H3Br, which (4 g) was let react with 0.There are some commonly used reagents with their cas registry numbers 89407-56-7 and 367-25-9 in this article.5 g Mg in THF to form II (in soln.). To this was added 5 g III in THF at <30° and the whole refluxed 2 h to give IV, which was heated with 2 g KHSO3 2 h at 200° under N to give 6% I. .