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CAS No.: | 36794-52-2 |
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Name: | Diphenidine (hydrochloride) |
Article Data: | 11 |
Molecular Structure: | |
Formula: | C19H23N |
Molecular Weight: | 265.398 |
Synonyms: | 1,2-diphenyl-1-piperidinoethane; |
Boiling Point: | 547.8oC at 760 mmHg |
Flash Point: | 285.1oC |
PSA: | 77.84000 |
LogP: | 4.10600 |
N-benzoylpiperidine
benzylmagnesium chloride
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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Stage #1: N-benzoylpiperidine With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 20℃; for 0.333333h; Stage #2: benzylmagnesium chloride at -78 - 20℃; for 4h; chemoselective reaction; | 95% |
piperidine
benzyl bromide
benzaldehyde
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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Stage #1: piperidine; benzyl bromide; benzaldehyde With trifluoroacetic acid; zinc In acetonitrile for 1.5h; Mannich type reaction; Inert atmosphere; Stage #2: With ammonium chloride In water; acetonitrile | 77% |
1,1'-benzylidenedipiperidine
benzyl bromide
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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With chloro-trimethyl-silane; diisopropylamine; zinc In benzene at 20℃; for 6h; | 46% |
1-(butoxyphenylmethyl)piperidine
phenylmagnesium bromide
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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With diethyl ether |
benzylmagnesium chloride
(±)-1-(1,2-diphenylethyl)piperidine
piperidine
benzyl(bromo)zinc
benzaldehyde
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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In acetonitrile at 20℃; for 3h; |
piperidine
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: mercury (II)-chloride; calcium sulfate 2: diethyl ether View Scheme | |
Multi-step reaction with 3 steps 1: benzene / Unter Entfernen des entstehenden Wassers. 2: potassium carbonate 3: diethyl ether View Scheme |
1,1'-benzylidenedipiperidine
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: potassium carbonate 2: diethyl ether View Scheme |
benzaldehyde
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: mercury (II)-chloride; calcium sulfate 2: diethyl ether View Scheme |
1,5-dibromo-pentane
(R,S)-1,2-diphenylethylamine
(±)-1-(1,2-diphenylethyl)piperidine
Conditions | Yield |
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With potassium carbonate In acetonitrile at 20℃; for 72h; Inert atmosphere; |