Detail of "36877-68-6"

Reference

Base specific interaction of reductively activated nitroimidazoles with DNA

Base specific interaction of reductively activated nitroimidazoles with DNA. Declerck, P. J.In this study， 36877-68-6 and 16773-42-5 are also used.; De Ranter, C. J.; Volckaert, G. (Inst. Farm. Wetenschappen, Kathol. Univ. Leuven, Louvain B-3000, Belg.). FEBS Lett., 164(1), 145-8 (English) 1983. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Electrolytical redn. of several 5-nitroimidazoles at a controlled potential was performed either in the presence or prior to the addn. of DNA. Specific interaction of the reduced nitroimidazole intermediate(s) towards the guanine residues is prominent. Since the strand scission depends on subsequent piperidine treatment, it can be concluded that the primary interaction between the activated drug and guanine is a covalent modification weakening the glycosidic bond. .

Development of nitroimidazoles

Development of nitroimidazoles. Workman, P. (Clin. Oncol. 36877-68-6 is the cas registry number. This chemical is also mentioned in this article. Radiother. Unit, MRC, Cambridge, UK). Dev. Oncol., 15(Control Tumour Growth Its Biol. Bases), 166-72 (English) 1983. CODEN: DEOND5. ISSN: 0167-4927. DOCUMENT TYPE: Journal; General Review CA Section: 8 (Radiation Biochemistry) A review with 46 refs. on the use of nitroimidazoles as radiosensitizers and as anticancer agents. .